Investigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia
Journal Title: Iranian Journal of Blood and Cancer - Year 2010, Vol 2, Issue 4
Abstract
Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia patients. Materials and Methods: We investigated serum level of leptin, LIF, and IL-6 levels, body mass index, hemoglobin, and hematocrit in 30 myeloid leukemia patients (15 patients with acute and 15 with chronic myeloid leukemia) before chemotherapy, and compared the results with 15 healthy controls. Results: Leptin, LIF and IL-6 serum levels, and lipid profile in myeloied leukemic patient was significantly different from the control group (p<0.05). The relationship between leptin and BMI was statistically significant in control group, whereas in the patient group, there were no significant relationship between leptin and BMI. Conclusion: Lipid profile and leptin, LIF, and IL-6 serum levels of leukemic patients were significantly different from normal population.
Authors and Affiliations
Shaban Alizadeh, Shahab Bohloli, Ali Abedi, Seyed Hadi Mousavi, Hossein Dargahi, Behzad Jafarzadeh, Nourooz Hamrang
Keywords
Related Articles
- EP ID EP376978
- DOI -
- Views 81
- Downloads 0
Non-pharmacological Interventions for Needle-related Procedural Anxiety in Children with Thalassemia
Background: The purpose of the present study was to assess the efficacy of non-pharmacological interventions on the anxiety among thalassemic children undergoing venipuncture. Patients and Methods: This was a clinical tr...
Cytotoxic Effects of Aqueous Extract of Portulaca oleracea on Oral Cancer Cell Line
Background: Portulaca oleracea as a herbal plant has been widely used in traditional medicine to cure many diseases. The therapeutic effects of this plant are exerted through its active ingredients with antioxidant prope...
Platelet Satellitism in a Three and Half Year Old Girl with Hemolytic Anemia and Normal Platelet Count
Platelet adherence surrounding leucocytes in a rosette formation or platelet satellitism is a rare phenomenon. This finding has been observed almost exclusively in Ethylenediaminetetraacetic acid treated blood at room te...
Expression of Recombinant Coagulation Factor IX in Human Amniotic Membrane-derived Mesenchymal Stem Cells: A New Strategy to Gene Therapy of Hemophilia B
Background: Hemophilia B is an X-linked hereditary disorder of blood coagulation system which is caused by factor IX (FIX) deficiency. Factor IX is a plasma glycoprotein that participates in the coagulation process leadi...
Hyperimmunes Plasma Procurement and Products
This article has no abstract.