Investigation of Plasma Conjugated Linoleic Acid Levels in Obese and Healthy Subjects
Journal Title: Journal of Clinical and Analytical Medicine - Year 2012, Vol 3, Issue 2
Abstract
Aim: Obesity is very widespread health problem especially in developed countries. It occurs due to more body fat accumulation than normal levels, it implicates with many factors in the etiology and it needs to treatment. Conjugated linoleic acid (CLA) refers to a class of positional and geometric conjugated isomers of the omega-6 essential fatty acid, linoleic acid. An array of purposed beneficial effects of CLA, such as capability of reducing or eliminating cancer, preventing heart disease and improving immune function on human healthy have been reported. This study has aimed to investigate biologically active isomers of CLA (10-trans, 12-cis CLA and 9-cis,11-trans CLA ) in obese and healthy subjects. Material and Method: The study was performed on 105 obese people (22M, 83F) aged 18-70 years and 80 control subjects (20M,60F) aged 18-70 years. Body mass index of the obese subjects was more than 35 kg/m2 and that of healthy controls was less than 25 kg/m2. Plasma 10-trans, 12-cis CLA (t10,c12 CLA) and 9-cis,11-trans CLA (c9,t11 CLA) levels were measured by GS-MS technique. Results: t10,c12 and c9,t11 isomers of CLA levels of the obese subjects were found as follows: 13.42±3.94 and 9.23 ±5.61 mg/L respectively. The same parameters of the controls were as follows: 13.15±3.67 and 9.80+5.06 mg/L respectively. Discussion: The differences between plasma CLA isomers levels of obese and control subjects were not significant. But, isomers of CLA negatively correlated with waist-to-hip ratio, which accepted as a good indicator of body fat distribution, in obese subjects. These findings suggest that the levels of t10,c12 CLA and c9,t11 CLA isomers inversely associated with body fat mass in obesity.
Authors and Affiliations
Hümeyra Fatma Yerlikaya, İdris Mehmetoğlu
Keywords
Related Articles
- EP ID EP155941
- DOI 10.4328/JCAM. 645
- Views 118
- Downloads 0
Skalpte Tanıda Yanıltıcı Olarak Hidradenitis Süppürativayı Düşündüren Multipl Rüptüre Epidermal Kistler: Olgu Sunumu
Epidermal kistler en sık rastlanan yumuşak doku tümörlerinden biri olması, kolaylıkla teşhis edilip cerrahi eksizyonla tedavi edilebilmesine rağmen zaman zaman başka lezyonlarla da karışabilmektedirler. Burada, skalpte...
Ascaris Lumbricoides as a Rare Cause of Hepato-Pancreatico-Biliary Complications: Report of Two Cases and a Brief Review of the Literature
Ascaris is one of the most common parasitic infestations of the gastrointestinal tract which causes a variety of non-specifi c abdominal symptoms during the intestinal phase of the disease. In this phase the adult worms...
Kasık Ağrısı ve Topallama ile Ortaya Çıkan Pelvisin Primer Kist Hidatiği: Olgu Sunumu
Ekinokok vücutta tüm organları tutabilir. Ancak kasıkla birlikte kemiği tutan ve anterior kalça ağrısına neden olan primer pelvik kist hidatik çok nadirdir. Bu olguda kemiği tutmuş ancak patolojik kırığa neden olmamış...
Loss of Consciousness Induced by a Single Dose Flurbiprofen
Loss of consciousness after the administration of flurbiprofen has not been reported. In this case report, we describe loss of consciousness due to the administration of one oral dosage of flurbiprofen. A 17 year-old g...
Farklı Kanal Dolgu Maddelerinin ve İrrigasyon Solüsyonlarının Mikrosızıntı Değerlendirilmesi
Amaç Bu çalışmanın amacı, hangi irrigasyon solüsyon hangi kanal dolgu patıyla birlikte kullanılırsa en az mikrosızıntının oluşacağını tespit etmektir. Gereç ve Yöntemler Bu çalışma için 170 tek köklü maksiller ve mandibu...