Investigation of Subclinical Cardiotoxicity in Chronic Leukemia Patients with Non-invasive Tests
Journal Title: Istanbul Medical Journal - Year 2016, Vol 20, Issue 6
Abstract
Introduction: This study aimed to investigate the left ventricular function and electrocardiographic findings in patients with chronic leukemia receiving and not receiving chemotherapy during a one-year follow-up. Methods: A total of 111 patients with chronic leukemia were included in the study. Electrocardiographic and mechanical findings of the heart were evaluated by surface 12-lead electrocardiogram and 2-dimensional transthoracic echocardiography, and cardiac troponin (cTn) was evaluated for myocyte damage and B-type natriuretic peptide marker for heart failure at baseline, 6th month and 12th month. Results: During the study, a total of six patients reached the endpoint, including two patients to primary endpoint (atrial fibrillation) and four patients to secondary endpoint (non-cardiac death). However, asymptomatic hemodynamic and electrocardiographic changes were observed in all patients who did not reach the endpoint. There was a quantitative decrease in left ventricular ejection fraction and an increase in the rate of diastolic dysfunction. Increased incidence of fragmented QRS, and prolongation of QT interval and QT dispersion, which are important indicators of possible cardiac events, were detected. cTn levels were observed to be at the upper limit of the normal range. All these findings show that myocardial damage has begun in the study patients, even if it is asymptomatic. Conclusion: In order to prevent future cardiac events in this patient group, these changes need to be taken into consideration and closely monitored.
Authors and Affiliations
Timor Omar, Rasim Enar, Barış İkitimur, Burçak Kılıçkıran Avcı
Keywords
Related Articles
- EP ID EP675982
- DOI 10.4274/imj.galenos.2019.09734
- Views 123
- Downloads 0
The Usefulness of Endoscopic Retrograde Cholangiopancreatography at Preoperative or Postoperative Cystic Echinococcus Patients
Introduction: The aim of this study was to evaluate the efficacy of endoscopic retrograde cholangiopancreatography (ERCP) at cystic echinococcus (CE) patients in the preoperative or postoperative period. Methods: Hepati...
Central Giant Cell Granuloma with Cosmetic Deformity and its Treatment without A Scar
Central giant cell granuloma is a non-neoplastic proliferative lesion of unknown aetiology, and may cause severe local destruction. It occurs mostly in the mandible, but can also be found in the maxilla. Surgical excisio...
A Case of Spinal Thoracic Empyema Following Epidural Injection
Spinal thoracic empyema is a complicated, important spinal pathology that is seen sporadically or following surgery or trauma. In this report, we aimed to present a case with spinal thoracic empyema following epidural in...
Fluid Management in Cesarean Section with Spinal Anesthesia: A Retrospective Study
Introduction: Spinal anesthesia is a widely used and preferred method for elective cesarean section operations. However, one of the critical side effects is hypotension. In this study, we aimed to compare the effects of...
Preliminary Outcomes of Hip Arthroscopy in the Treatment of Femoroacetabular Impingement with Early Stage Osteoarthritis
Introduction: Femoroacetabular impingement (FAI) has been recognized as a risk factor of osteoarthrosis that causes a painful joint and decreased range of motion. Arthroscopic procedures were used for the treatment of FA...