Investigation of The Anti-Hyperglycemic Activities of Aqueous Leaves Extract Of Vernonia Amygdalina (VA) In Rats
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 3
Abstract
Many plants have been discovered to be effective in the prevention and treatment of various diseases This study investigated the anti-hyperglycemic activities of aqueous leaves extract of Vernonia Amygdalina (VA) in rats. 35 wistar rats of weights 175-285g where divided into seven (7) groups of five(5) rats each. Group A was a normoglycemic group and received water and feed ad libitium. Groups B, C, D , E, F and G were non-diabetic and received 80mg/kg of VA extract, Diabetic untreated group, Diabetic and received 40mg/kg of VA extract, Diabetic and received 80mg/kg of VA extract, Diabetic and received 120mg/kg of VA extract and Diabetic and received 5mg/kg of glibenclamide (a standard antidiabetic drug) P.O . The effect of the VA extract on blood glucose level, triglyceride, cholesterol, (HDL), LDL and body weight was estimated and the data were analyzed using SPSS version 20.The extract caused significant (P<0.05) and progressive time dependent reduction on blood glucose, serum triglyceride, cholesterol and body weight in both normoglycemic and alloxan-induced diabetic rats, the extract also caused a significant increase on HDL level in both diabetic and non-diabetic rats at all dose. In conclusion; the findings from this study showed that the aqueous leaves extract of VA possess anti-hyperglycemic, lipid lowering and hypoglycemic activities and suggests that 80mg/kg was the most potent dose at which VA demonstrated these activities. The significant reduction in blood glucose, triglyceride and cholesterol levels, body weight and an increase in HDL observed in this study justifies the ethnomedicinal uses of VA in the management of diabetes though effort should be made to optimize the dose for better effectiveness.
Authors and Affiliations
Ani Celestine Okafor
Keywords
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