Investigation of the effect of pd1.1, pd1.5, and pd1.9 mutations on pd1 gene function with a system biology approach
Journal Title: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation - Year 2021, Vol 1, Issue 1
Abstract
Programmed cell death 1 (pd1) is an immune-inhibitory receptor that is expressesd in activated T cells. This gene may play a role in the inhibition of actual anti- microbial and anti-tumor immunity. In human, this gene is positioned located on the long arm of chromosome 2. This gene has contained many variations that three of them which are too more common. This study was aimed to investigate the influence of pd1.1, pd1.5, and pd1.9 variations on the function of pd1gene with based on a bioinformatics approach. In this study, the EPD and PROMO webserver was used to evaluate the pd1.1 variation as a promoter mutation. It has been detected in the promoter region by EPD, while the transcription factor arrangement was evaluated by the PROMO server. But, some bioinformatics tools such as ProtScale – ExPASy and Ramachandran plot assay web servers were used to evaluate the effects of codding polymorphisms. Obtained data from EPD showed that the promoter of pd1 contains 60 nucleotides. Evaluation of upstream of pd1 revealed that the number of transcription factors could alter around the pd1.1 variation. With regard to the pd1.5 polymorphismpolymorphisms, the result showed that it is considered as a synonymous variation, but the pd1.9 was knownconsidered as a nonsynonymous mutation. Thus, the pd1.9 could alter the hydrophobicity and Ramachandran plots of PD1. The pd1.5 mutation may impact the expression of the pd1gene. Bbecause it changes the transcription factor arrangement on the upstream of pd1. Also, the pd1.9 substitution could alter the hydrophobicity and Ramachandran plots of protein.
Authors and Affiliations
Mohammad Reza Roshandel; Hawri Mustafa Bakr; Ramin Lak; Ruqaya Muhammed Ghareeb Taher Al Barzinji; Khonaw Kader Salh; Kharman Saeed Ibrahim; Feyan Mirdan Abdullah
Keywords
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- EP ID EP714122
- DOI 10.22034/CAJMPSI.2021.01.05
- Views 106
- Downloads 0
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