Investigation of the Effects of Cellulose Derivatives on the Kinetics of Drug Release from Cellulose-Based Hydrogel Using a Response Surface Method
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2013, Vol 1, Issue 1
Abstract
The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on drug release were studied and compared to those obtained with a reference formulation prepared with HEC. It was shown that the use of HPMC in the gel formulation contributes to the improvement of drug release and consequently its biodisponibility. Indeed, the increase in HPMC concentration forms a controlled system release because polymer chains relaxation. The drug is released under the effects of two phenomena: diffusion and relaxation of polymeric chains. Thus, the kinetic release passes from the kinetics of case II towards Fickian diffusion.
Authors and Affiliations
S. Lefnaoui , N. Moulai-Mostefa
Keywords
Related Articles
- EP ID EP596674
- DOI 10.15415/jptrm.2013.11008
- Views 215
- Downloads 0
Neuropharmacological Activities of Abies pindrow Aerial Parts in Mice
The methanol extract (200 or 400 mg/kg, p.o.) and ethyl acetate fraction (25 or 50 mg/kg, p.o.) of A. pindrow aerial parts were screened for anticonvulsant, antidepressant, locomotor, hypnotic and antistress activities....
Self-medication in Developing Countries a Systematic Review
Self-medication is common in developing countries where it has both economic and social implications. On the one hand, it is viewed as a large component of self-care, which relies heavily on the consumer’s expertise in t...
Ebola Hemorrhagic Fever: Recent Update On Disease Status, Current Therapies And Advances In Treatment
Swiftly growing viruses are a major intimidation to human health. Such viruses are extremely pathogenic like Ebola virus, influenza virus, HIV virus, Zika virus etc . Ebola virus, a type of Filovirus, is an extremely inf...
Dementia: An Overview
Dementia is a neurodegenerative disorder characterized by progressive and continuous loss of cognitive functions. The neuropsychiatric symptoms include apathy; agitation and depression. As the disorder progresses, the pa...
Preparation and Evaluation of Chitosan and PLGA Based Implants for the Delivery of Cefotaxime
The poor bioavailability of cefotaxime and limitation of conventional system limits the delivery of antibacterial drug cefotaxime for bone infection treatment. In the current study in situ chitosan implant containing cef...