INVESTIGATION OF THE IMPACT OF CELLULOSE ACETATE COATING ON THE RELEASE PATTERN OF FREELY SOLUBLE DRUG: METOPROLOL SUCCINATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 4
Abstract
This study is aimed to develop and evaluate cost-effective cellulose acetate (CA)-polyvinyl pyrrolidone (PVP) film coating that can effectively control the release of freely water soluble drug, metoprolol succinate (MS) and to match that of release profile with its marketed tablet formulation. Simple core tables of MS were compressed and coated with a solution composed of semipermeable rate controlling polymer, CA and water soluble pore forming polymer, PVP. Drug-excipient interaction was investigated by both physical observation and differential scanning calorimetry (DSC). The effect of formulation parameters such as the ratio of CA to PVP, tablet coating weight gain, effect of pH on the in-vitro drug release were evaluated. Surface morphology of the CA coating membrane was examined by scanning electron microscope (SEM). Release profile of the optimized formulation at different pH conditions was determined and the similarity factor (f2) with marketed tablet release profile was calculated. It was observed that drug release rate increased with a decrease in the ratio of cellulose acetate to PVP and decreased with increased weight gain of the coating membrane. Among all the formulations, the formulation with CA and PVP at a ratio of 85:15 %w/w and 9 % weight gain showed matching release profile to the marketed tablet formulation with f2 value of 72.25. Developed MS formulation showed pH independent drug release. This study proved that CA-PVP polymer coating could effectively control the release rate of freely water soluble drugs for up to 24 h. Once a day CR formulation of metoprolol succinate pharmaceutically equivalent to marketed formulation was developed.
Authors and Affiliations
Kiran Vangara , Kishore Konda , Venkata Pulipati , Sushma Samala
Keywords
Related Articles
- EP ID EP89544
- DOI 10.7897/2230-8407.06456
- Views 123
- Downloads 0
STANDARDIZATION AND TOXICOLOGICAL EVALUATION FOR EFFICACY AND SAFETY OF PIMPINELLA ANISUM L.
The demand of herbal medicine is increasing day by day due to their efficacy, safety (rare chances of side effects) in the treatment and good faith of society on herbal medicine and also their products. Therefore standar...
AYURVEDIC FORMULATIONS FOR THE MANAGEMENT OF EPILEPTIC DISORDERS
Epilepsy is a most common disorder in neuropsychiatric outpatient department. Most of the times it’s Diagnosis and treatment is difficult. Apasmara is a similar clinical condition described in all major classics of Ayurv...
NEW INSIGHTS INTO MOLECULAR TARGETS FOR DEPRESSION
Major depressive disorder is a heritable neuropsychiatric syndrome characterized by relatively subtle cellular and molecular alterations localized to a complex network of neural substrates. Various forms of psychotherapy...
ANALGESIC AND CYTOTOXIC ACTIVITIES OF THREE REPUTED BANGLADESHI MEDICINAL PLANTS
Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand in the present world for plant based medicines, health products, pharmaceuticals, food suppl...
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF BOUCEROSIA TRUNCATO-CORONATA (SEDGW.) GRAVELY MAYUR
As a measure of testing the medicinal properties of B. truncato-coronata ethanolic extract obtained from both in vivo and in vitro plants were studied for phytochemical test and antioxidant activity by DPPH and FRAP. Qu...