Investigation of Thrombolytic and Antioxidant Potentials of Centella Asiatica
Journal Title: Galore International Journal of Health Sciences and Research - Year 2018, Vol 3, Issue 4
Abstract
The aim of the present investigation was to find out the antioxidant as well as the thrombolytic properties of Centella asiatica which is known as “Thankuni” in Bangladesh and used as a folk medicine. The methanolic extract of Centella asiatica plant was partitioned into petroleum ether soluble fraction(PSF), Chloroform soluble fraction (CSF), Ethyl acetate soluble fraction (ESF) and aqueous soluble fraction(ASF). The extracts were evaluated for their thrombolytic and antioxidant potentials and the results were compared with standard drugs; streptokinase for thrombolytic. In thrombolytic investigation, the aqueous soluble fraction (ASF) showed highest percent of clot lysis (50.53%) as compared to (63.74%) exhibited by the standard streptokinase. The presence of antioxidant potentials of Centella asiatica were evaluated by antioxidant capacity and reducing power to free radical. The total antioxidant capacity of Methanol extract of Centella asiatica (MCA), PSF, CSF, ESF and ASF were observed as mg of extract, respectively. The DPPH free radical in term of IC50 values of the extractives was found 108.25 µg/ml, 909.03 µg/ml, 292.44 µg/ml, 104.61 µg/ml and 173.09 µg/ml for MCA, PSF, CSF, ESF and ASF respectively in comparison to 400.02 µg/ml for BHT. The result obtained in this study found that Centella asiatica plant possesses potential thrombolytic and antioxidant effect.
Authors and Affiliations
Md. Sakhawat Hossain
Keywords
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