Invitro Evaluation of Antioxidant and Antimicrobial Potential of leaves of Atalantia racemosa Wight ex Hook
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 6
Abstract
Objective: Atalantia racemosa belongs to the family Rutaceae, comprises of 11 species which are closely-related. The present study was mainly done to evaluate the antioxidant and antimicrobial potential of leaves of Atalantia racemosa. Methods: Free radical scavenging activity for the leaves of A. racemosa was studied by invitro assays such as DPPH˙, hydroxyl (OH˙) radical scavenging, ABTS˙+ radical cation, phosphomolybdenum and ferric reducing power assay respectively. Also, the antimicrobial studies were carried out by Agar well diffusion method in order to study the inhibition effect of plant extract against the test pathogens. Results: The IC50 value (Inhibitory concentration) of methanolic extract for DPPH˙ radical was 95.92μg/mL. For hydroxyl (OH˙) radical scavenging theIC50 value was 40.60μg/mL and for ABTS˙+ radical theIC50 value was 41.81μg/mL. The antimicrobial effect was studied against the test pathogens, having higher inhibition of 20mm against gram positive bacteria Staphylococcus aureus. Conclusion: The study revealed that Atalantia racemosa could be considered as a potent antioxidant source against many free radicals. By performing these antioxidant activities, the anti-proliferative nature on selected cell lines shall be determined.
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