Involvement of adenosine receptor agonists on the development of hypersensitivity to acute dose of morphine during morphine withdrawal period.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 5
Abstract
In the present study, the involvement of the selective adenosine A(1) (CPA) and A(2A) (CGS 21680) and non-selective adenosine A(1)/A(2A) (NECA) receptor agonists on the development of hypersensitivity to acute morphine injection given during opiate withdrawal was investigated. Intraperitioneal (ip) injections of morphine at increasing doses (10, 20, 30, 40, 50 mg/kg) for 6 consecutive days produced a state of dependence. On the 6th day, in the morning, animals were injected with the last dose of morphine (50 mg/kg, ip). Each day, 20 min before each injection of morphine, adenosine receptor agonists were also administered. Seven days after cessation of the morphine treatment, on the 13th day of the experiment, all animals were challenged with a dose of morphine (10 mg/kg, ip). A clear increase in locomotor activity was observed, indicating that hypersensitivity had developed. Our study has demonstrated the presence of an attenuating effect of adenosinergic drugs, such as CGS 21680 and NECA, but not CPA, on the development of hypersensitivity. The results indicate that stimulation of the adenosine A(2A) receptor plays some role in modulating the neuroadaptive changes appearing during chronic opioid treatment and that adenosine A(2A) receptor agonists may serve as useful drugs in relapse protection. Our investigations focused on adenosine A(2A) agonists as possible vehicles for pharmacotherapy for morphine addiction.
Authors and Affiliations
Joanna Listos, Sylwia Talarek
Keywords
Related Articles
- EP ID EP123762
- DOI -
- Views 81
- Downloads 0
Effect of short- and long-term treatment with antidepressant drugs on the activity of rat CYP2A in the liver.
The aim of the present study was to investigate the influence of tricyclic antidepressants (TADs: imipramine, amitriptyline, clomipramine, desipramine), selective serotonin reuptake inhibitors (SSRIs: fluoxetine, sertral...
Effect of administration of etidronate and retinol on bone mechanical properties in ovariectomized rats.
The experiments were carried out on rats, divided into 7 groups: I - sham-operated control rats, II - ovariectomized (OVX) control rats, III - OVX + etidronate (10 mg/kg po), IV - OVX + retinol (700 IU/kg po), V - OVX +...
Fluvastatin does not elevate periosteal osteogenesis induced by Moloney sarcomavirus (MSV) in mice.
Several studies have demonstrated the pleiotropic effects of statins. Since Wang and associates reported that in rabbits lovastatin reduced steroid-induced bone loss, numerous authors have confirmed these data, however,...
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Postnatal treatment with caffeine from P7 to P11 (10 or 20 mg/kg daily) resulted in transient changes in two pentylenetetrazole (PTZ)-induced models of epileptic seizures characterized by spike-and-wave EEG rhythm in imm...
Free radicals generated by xanthine/xanthine oxidase system augment nitric oxide synthase (NOS) and cyclooxygenase (COX)-independent component of bradykinin-induced vasodilatation in the isolated guinea pig heart.
Recently, we have reported that bradykinin (Bk)-induced vasodilation was selectively potentiated by a low concentration of reactive oxygen species (ROS) generated by xanthine/xanthineoxidase system (XOX) in the coronary...