Involvement of adenosine receptors in dizocilpine-induced motor activity in mice.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 1
Abstract
The effect of adenosine receptor ligands on dizocilpine-induced locomotion was studied in mice. Dizocilpine-induced hyperactivity (0.1 mg/kg ip) in mice was antagonized by all adenosine receptor agonists: CPA - A(1) receptor agonist, CGS 21680 - A(2) receptor agonist, and NECA - A(1)/A(2) receptor agonist, but the effect of NECA was the most apparent. Locomotion induced by the threshold dose of dizocilpine (0.05 mg/kg ip) was enhanced by DPMX (A(2A) adenosine receptor antagonist) and by the theophylline (A(1) and A(2) receptor antagonist), but not by A(1) receptor antagonist - CPT. These data suggest that adenosinergic system is involved in the mechanism of dizocilpine-induced hyperactivity, and it seems that A(2A) adenosine receptor plays a more important role.
Authors and Affiliations
Danuta Malec, Ewa Poleszak
Keywords
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