Involvement of NF-κB Signaling Pathway in the Pathogenesis of Systemic Lupus Erythematosus
Journal Title: Nephrology – Open Journal - Year 2016, Vol 2, Issue 1
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by accumulation of anti-nuclear autoantibodies, hyperactivation. It can affect any organ, including brain, skin, joint, and kidney. The nuclear NF-κB pathway has long been considered a crucial pro- inflammatory signaling pathway. Its transcribed the genes involves in various autoimmune disease. Within the past year, many research studies have been conducted the role of NF-κB signaling in lupus. In this review, we will highlight some recent studies that support the potential link of NF-κB signaling pathway which play a crucial role in the pathogenesis of SLE.
Authors and Affiliations
Rakesh K. Mishra
Keywords
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- EP ID EP558252
- DOI 10.17140/NPOJ-2-112
- Views 164
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