Involvement of NF-κB Signaling Pathway in the Pathogenesis of Systemic Lupus Erythematosus
Journal Title: Nephrology – Open Journal - Year 2016, Vol 2, Issue 1
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by accumulation of anti-nuclear autoantibodies, hyperactivation. It can affect any organ, including brain, skin, joint, and kidney. The nuclear NF-κB pathway has long been considered a crucial pro- inflammatory signaling pathway. Its transcribed the genes involves in various autoimmune disease. Within the past year, many research studies have been conducted the role of NF-κB signaling in lupus. In this review, we will highlight some recent studies that support the potential link of NF-κB signaling pathway which play a crucial role in the pathogenesis of SLE.
Authors and Affiliations
Rakesh K. Mishra
Keywords
Related Articles
- EP ID EP558252
- DOI 10.17140/NPOJ-2-112
- Views 158
- Downloads 0
Averting the Legacy of Kidney Disease – Focus on Childhood
World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of Adult Kidney Disease (AKD) that can begin in earliest childhood. Chronic Kidney Disease (CKD) in childhood differs from that in adults,...
Androgen and Androgen Receptor in Kidney Cancer
Kidney cancer is one of the top ten most common cancers in men and women. There are four types of kidney cancer, including Renal Cell Carcinoma (RCC), Transitional cell carcinoma, renal sarcoma, and Wilm’s tumor. The mos...
Extensive Search for Dry Weight: Should We Change the Strategy?
Introduction: A wrong estimate of the dry weight in hemodialysis patients increases their morbidity and mortality. The aim of our study was to compare the results of the estimated dry weight using the clinical examinatio...
Effect of Diethylenetriaminepentaacetic Acid (DTPA) on Crystal Growth and Morphology of Calcium Oxalate
Introduction: One of the most common and painful diseases observed in the tropical regions is kidney stone formation. This can be due to various factors such as the amount of water consumption, climatic conditions, lifes...
Fibroblast Growth Factor 23 as a Therapeutic Target
This fibroblast growth factor-23 (FGF-23) has been found as a circulating hormone and pathogenic factor in many disease conditions. This review focuses on recent advances in FGF-23 as a therapeutic target, including fibr...