Iron Sucrose vs Ferric Carboxymaltose: In Search of Better Treatment Option in Cases of Post Partum Iron Deficiency Anemia
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Anemia is the most common hematological abnormality diagnosed during pregnancy. As per WHO, anaemia during pregnancy is defined as haemoglobin concentration of less than 11 gm%. The objective of this study was to compare the safety and efficacy of intravenous iron sucrose and I.V. ferric carboxymaltose in treating postpartum iron deficiency anemia. Material and Methods: A comparative, interventional, prospective study was carried out in 100 postpartum patients with Anemia (Hb level between 7 to 11 gm/dl) in the department of obstetrics and gynaecology, Government Medical College, Bhavnagar, Gujarat, India from June 2016 to July 2017. The subjects were randomized in two groups. First group receiving 1000 mg of intravenous iron sucrose divided in five doses on alternate days (200 mg each) and Second group receiving 1000 mg of intravenous ferric carboxymaltose. Results: Maximum number of patients in our study were belonged to low socioeconomic group, significantly higher number of women achieved rise of Hb >2gm/dl in FCM group.26 women in FCM group achieve Hb rise of >2gm/dl as compared to only 11 in iron sucrose group, which was highly significant (pvalue <0.001). Mean rise of Hb was 1.9 gm/dl for FCM group and 1.66gm/dl for iron sucrose group, which was also significant. Serum ferritin level in ferric carboxymaltose group was rises more (83.9 ng/ml) as compared to (76.06 ng/ ml) iron sucrose group. Unpaired‘t’ test was used to test the significance of rise and compare the rise between two groups. Conclusions: Ferric carboxymaltose is an efficient and better alternative to Iron Sucrose in treating postpartum anemia. It has an added advantage of single dose regime with lower side effects.
Authors and Affiliations
Mayank Lunagariya, Kanaklatta D. Nakum, Aditi Vithal, Juhi Patel, Mehul Patel
Keywords
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