IS GNB3 C825T POLYMORPHISM ASSOCIATED WITH ELITE STATUS OF POLISH ATHLETES?
Journal Title: Biology of Sport - Year 2014, Vol 31, Issue 1
Abstract
The [i]GNB3[/i] gene encodes the beta 3 subunit of heterotrimeric G-proteins that are key components of intracellular signal transduction between G protein-coupled receptors (GPCR) and intracellular effectors and might be considered as a potential candidate gene for physical performance. Objectives: The aim of this study was to compare frequency distribution of the common C to T polymorphism at position 825 (C825T) of the [i]GNB3[/i] gene between athletes and nonathletic controls of the Polish population as well as to compare the genotype distribution and allele frequency of C825T variants within a group of athletes, i.e. between athletes of sports of different metabolic demands and competitive levels. Methods: The study was performed in a group of 223 Polish athletes of the highest nationally competitive standard (123 endurance-oriented athletes and 100 strength/power athletes). Control samples were prepared from 354 unrelated, sedentary volunteers. Results: The χ[sup]2[/sup] test revealed no statistical differences between the endurance-oriented athletes and the control group or between sprint/strength athletes and the control group across the [i]GNB3[/i] 825C/T genotypes. There were no male-female genotype or allele frequency differences in controls or in either strength/power or endurance-oriented athletes. No statistically significant differences in either allele frequencies or genotype distribution were noted between the top-elite, elite or sub-elite of endurance-oriented and strength/power athletes and the control group. Conclusions: No association between elite status of Polish athletes and the [i]GNB3[/i] C825T polymorphic site has been found.
Authors and Affiliations
Marek Sawczuk, Agnieszka Maciejewska-Karłowska, Paweł Cięszczyk, Agata Leońska-Duniec
Keywords
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