Is Incorporation of Aloe Vera Encapsulated By Chitosan NanoSpheres To Compomer A Valid Antibacterial Approach? An InVitro Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 6
Abstract
Introduction: This study investigated the effect of incorporation of Aloe Vera (AV) as a filler to compomer on its antibacterial activity, solubility and surface roughness. Method: Compomer (Dyract XP), the control; Group 1, was modified by adding 15wt% of experimentallyprepared AV encapsulated by chitosan nano-spheres; Group 2. Discs (15x1mm) of each group were prepared and characterized. For each test, 21 discs/group were investigated. The antibacterial activity against Streptococcus mutans (ATTCC 25175) was evaluated by agar diffusion test by measuring the inhibition zone on inoculated discs. Solubility and surface roughness were investigated on discs stored in artificial saliva at 37ºC with five-minute lactic acid (pH=5.2) cycling three times daily, after one week and one, three and six months. Results were statistically significant at p≤0.05. Results: Group 2 had higher antibacterial activity (2.21±0.21 mm) than group 1(0.05±0.22 mm). The only significant change in solubility between the groups was at (0-7) days where group 1(0.390±0.016 µg/mm3 ) had higher solubility than group 2 (0.158±0.039 µg/mm3 ). Solubility within groups took place over a longer time for group 1; 90 days (0.690±0.022 µg/mm3 ) compared to group 2; 30 days (0.577±0.044 µg/mm3 ). The mean surface roughness values revealed that the baseline roughness of group 1(0.2572±0.0017µm) was lower than group 2 (0.2587±0.0020µm). This was reversed at 7 and 30 days. Conclusion: Incorporating 15wt% freeze-dried AV encapsulated by chitosan nano-spheres to compomer imparted an antibacterial effect against Streptococcus mutans. The change in solubility and surface roughness lied within the values accepted by ISO standards for resin-based restorative materials.
Authors and Affiliations
Nouran Hussein, Rania Ahmed Salama, Abdelhady Amin
Keywords
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- EP ID EP376592
- DOI 10.9790/0853-1706091626.
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