Is Interleukin-18 an Early Diagnostic Biomarker in Contrast Induced Nephropathy?
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 3
Abstract
Abstract Introduction: The rise in number of cases of hospital-acquired acute kidney injury in patients undergoing diagnostic and therapeutic procedures by the use of contrast medium is a growing concern among nephrologists. Despite being a delayed marker, the measurement of creatinine level is one of the most popular methods in medical fraternity, to identify the degree of damage caused to the kidneys. Therefore there is a need for development of method for early detection and treatment of the contraindication of contrast media. Since serum Interleukin-18 (IL-18) levels rise early in the disease course, it may be a promising novel biomarker and an early indicator of tubular damage as compared to creatinine and other novel biomarkers. Aim: The current study investigated the early rise in serum IL-18 after contrast induction. Materials and Methods: Randomly selected 30 male wistar rats were given 0.6 mL of contrast iohexol (325 mg of iodine per mL) intraperitoneally and blood samples were collected before and after the induction of contrast by bleeding retro-orbital plexuses under isoflurane (USP) inhalation anaesthesia. Blood samples were collected at 3 hours, 6 hours, 12 hours, 24 hours and 48 hours of post-contrast administration. Results were analysed by using paired Student’s t-test and p-value<0.05 was considered to be statistically significant before and after contrast induction. Results: Statistically significant increase in IL-8 levels at 3 (p<0.01), 6 (p<0.001), 12 (p<0.01) and 24 (p<0.01) hours pre- and post-contrast treatment was observed. However, no statistical difference was found at 48 hours pre- and post-contrast treatment (p>0.07). Conclusion: The present study reveals an increase in IL-18 levels from 48% to 100% at 6 hours post-contrast induct in comparison to other standard markers like creatinine levels which increases at 48-72 hours post-contrast insult, revealed by the literature. Therefore it can be concluded that IL-18 is a better early novel biomarker for tubular damage assessment, after contrast insult.
Authors and Affiliations
Mohammed Mujahid
Keywords
Related Articles
- EP ID EP582722
- DOI 10.7860/JCDR/2019/39667.12734
- Views 130
- Downloads 0
Correlation of Prostate Gland Size and Uroflowmetry in Patients with Lower Urinary Tract Symptoms
Introduction: Benign Prostatic Hyperplasia (BPH) is a common entity among men over 40 years of age with significant disability. It is a condition that occurs when the enlarged prostate gland compresses the urethra leadin...
Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis
Pigmented Villonodular Synovitis (PVNS) is a unique benign proliferative process of unknown aetiology involving the synovial lined joints diffusely or focally. The entity remains a diagnostic challenge. This condition is...
Impact of Counselling Services in Stress Reduction among First Year MBBS Students
ABSTRACT Introduction: Medical education being a highly competitive field is known to be quite stressful. Stress hinders the efficiency of many medical students. It has a negative influence on their academic performance...
Ultrasound-Guided Extraoral Removal of Extraparenchymal Sialoliths Caused by Acute Parotitis
ABSTRACT Migration of sialoliths is extremely rare and is presumed to be a consequence of abscess formation. We report a minimally invasive, ultrasound-guided, extraoral approach for the removal of extraparenchymal sialo...
Anti-inflammatory and Analgesic Activities of Topical Formulations of Pterocarpus Santalinus Powder in Rat Model of Chronic Inflammation
Introduction: The incidence of arthritis is quite high and there is a need for the search of natural products to halt the progression of disease or provide symptomatic relief without significant adverse effects. Aim: Thi...