Is It Feasible of Prophylactic Alpha-5 GABA(A) Receptor Blockade for Preventing POCD?
Journal Title: Science Insights - Year 2013, Vol 3, Issue 3
Abstract
GAMMA-AMINOBUTYRIC ACID (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system (CNS). It plays a role in regulating neuronal excitability throughout the nervous system. Also GABA activation is considered as the basis of general anesthesia including intravenous and inhalational anesthetics. Meanwhile, cumulating evidence indicated that GABA is the underlying mechanism of post-operative cognitive dysfunction (POCD). Based on these findings, researchers are beginning to focus on GABA as the target to treat POCD, but they ignored the role of GABA in the performance of general anesthesia, especially when the blockade of GABA was given prior to surgery. It is undoubtedly risking our patients in intra-operative awareness. Our exploratory data also verified our hypothesis in which the GABA inhibition would reduce the efficacy of inhalational anesthetics.
Authors and Affiliations
Fuzhou Wang
Keywords
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- EP ID EP689534
- DOI 10.15354/si.13.rp011
- Views 253
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