Is It Feasible of Prophylactic Alpha-5 GABA(A) Receptor Blockade for Preventing POCD?
Journal Title: Science Insights - Year 2013, Vol 3, Issue 3
Abstract
GAMMA-AMINOBUTYRIC ACID (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system (CNS). It plays a role in regulating neuronal excitability throughout the nervous system. Also GABA activation is considered as the basis of general anesthesia including intravenous and inhalational anesthetics. Meanwhile, cumulating evidence indicated that GABA is the underlying mechanism of post-operative cognitive dysfunction (POCD). Based on these findings, researchers are beginning to focus on GABA as the target to treat POCD, but they ignored the role of GABA in the performance of general anesthesia, especially when the blockade of GABA was given prior to surgery. It is undoubtedly risking our patients in intra-operative awareness. Our exploratory data also verified our hypothesis in which the GABA inhibition would reduce the efficacy of inhalational anesthetics.
Authors and Affiliations
Fuzhou Wang
Keywords
Related Articles
- EP ID EP689534
- DOI 10.15354/si.13.rp011
- Views 250
- Downloads 0
How to Overcome Stress and Anxiety from COVID-19?
The novel coronaviruscontinues to spread, infected cases continue to rise, and the long Covid is a major cause for concern. We are all exhausted and worn out from this type of overwhelming news, and we are very concerned...
Magnetic Resonance Neuroimaging of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a lifelong, relapsing, chronic inflammatory disease of the digestive tract that can be brought on by a number of different etiologies. Studies have shown that patients with IBD also ha...
Graphene: A Promising Candidate for Biomedical Use
As a new two-dimensional nanomaterial composed of sp2 carbon atom, graphene has unique electrical, optical and mechanical properties. At present, the research on graphene and its derivatives is mainly concentrated in the...
Impact of COVID-19 Pandemic on Mental Health: A Narrative Review
COVID-19 is an infectious disease that is serious, lethal, and transmissible. Since December 2019 the aftermath of the COVID-19 has been experienced by millions of global populations in all age groups, i.e., from newborn...
Homeostatic Synaptic Plasticity: Balanced by COX2-PGE2 System to a New Setpoint
The setpoint of neural activity plays a critical role in maintaining the complex neural circuits into stable activities. Homeostatic synaptic plasticity is a major component of the setpoint theory that dynamically adjust...