Is Low Cholesterol a Predisposing Factor for Primary Intracerebral Haemorrhage? A South Indian Perspective
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 5
Abstract
ABSTRACT Introduction: Stroke is an important cause of mortality and morbidity in low-income and middle-income countries like India. Primary Intracerebral Haemorrhage (PICH) refers to Intracerebral Haemorrhage (ICH) in the absence of a single clear underlying lesion. Cholesterol levels are inconsistently associated with risk of ICH. Aim: To assess their relationship between lipid parameters and PICH. Materials and Methods: One hundred sixty patients with PICH were retrospectively recruited and compared with apparently healthy subjects. Low cholesterol was defined by Total Cholesterol (TC) <200 mg/dL; Low Density Lipoprotein Cholesterol (LDL-C) <100 mg/dL; High Density Lipoprotein Cholesterol (HDL-C) <40 mg/dL; and Triglyceride (TG) level <150 mg/dL. Results: Out of 160 patients recruited majority of the patients were males (n=122). Mean age was 53.47±9.33 years. Most frequent risk factor of PICH was hypertension (72.5%). Most common site of bleed was in basal ganglion (n=63). The proportion of PICH patients with low TC was significantly higher than control (81.9% vs. 70%). TG levels and LDL-C were significantly low in PICH compared with controls (p-value<0.0001). Mean TC in PICH was 159 mg/dL vs. 180 mg/dL (p-value<0.0001); Mean TG level was 114 mg/dL vs. 168 mg/dL (p-value<0.0001); Mean LDL-C was 93 mg/dL vs. 119 mg/dL (p-value<0.0001). In a subgroup analysis, among older age (≥50 years) mean TC, TG levels and LDL-C were significantly low in PICH group compared to controls (p-value<0.0001). In multivariate analysis presence of low value of TG, LDL-C and TC remained a significant risk factor of PICH. Odds ratio for TG was 5.55 with 95% Confidence Interval (CI) of 3.295 to 9.36; odds ratio for LDL-C was 3.81 with 95% CI of 2.392 to 6.084. Conclusion: Our present study confirms low cholesterol as risk factor for PICH especially in older individual and both sexes.
Authors and Affiliations
Sandhya Manorenj, Imran Ahmed Siddiqui, P Muralikrishna, Keshav Anand, Navya Sagari
Keywords
Related Articles
- EP ID EP522925
- DOI 10.7860/JCDR/2018/31402.11479
- Views 53
- Downloads 0
Basaloid Squamous Cell Carcinoma of Tongue: A Report with Emphasis on Immunohistochemistry
Basaloid Squamous Cell Carcinoma (BScc) is a rare entity with its histopathological distinction from conventional squamous cell carcinoma. It is frequently considered a high-grade carcinoma with poor prognosis because of...
Antimicrobial Effect of Leaves of Phyllanthus niruri and Solanum nigrum on Caries Causing Bacteria: An In vitro Study
Introduction: Solanum nigrum and Phyllanthus niruri are common herbs which are indigeneous to India. Solanum nigrum commonly called ‘manathakkali Keerai’ in Tamil, forms an indispensable part of South Indian diet. Phylla...
New Vision for Improving the Oral Health Education of Visually Impaired Children- A Non Randomized Control Trial
Introduction: Visually impaired people have poorer oral hygiene when compared to others. Therefore, there is a necessity for individual training by making awareness in oral care and plaque control so as to improve their...
Oesophageal Schwannoma: A Postoperative Diagnosis
ABSTRACT Oesophageal schwannomas are rare benign tumours with very few case reports in the literature. It is very difficult to diagnose these tumours preoperatively and is often confused with other benign tumours like le...
Lingual Schwannoma-A Common Tumour at Uncommon Site in a Paediatric Patient: A Case Report and Review of the Literature
ABSTRACT Schwannomas are infrequent tumours of oral cavity that are not routinely included in the differential diagnosis of oropharyngeal masses. The tumour presents with non-specific clinical symptoms and is clinically...