Is Salivary Exosome the Answer to Early Detection of Oral Cancer?
Journal Title: Dentistry – Open Journal - Year 2015, Vol 2, Issue 2
Abstract
The presence of exosomesin almost all bodily fluidsincluding saliva1 represents a promising surrogate approach to investigate tumour markers. This has important clinical implications for developing non-invasive salivary diagnostics and therapeutics.2 Human saliva is an ideal fluid for developing non-invasive diagnostics and salivary biomarkers have been demonstrated in clinical studies showing promising diagnostic potentials but lacking in sensitivity mostly due to complexity of saliva.2,3 Hence, this led to the emerging interests on exosomes which are membrane-bound extracellular vesicles carrying specific membrane proteins with numerous types of nucleic acids4 and protein cargos,2,5,6 well protected from degradation by extracellular enzymes. Their size (50-150 nm diameter) is an advantage for purification and reducing the overall complexity ofsaliva.2 Most of the salivary exosome studies to date have been restricted to characterization of normal healthy samples.2 Emerging studies began looking at biochemical properties of disease-derived saliva exosomes.2,5,6 So, itseems no brainer thatsalivary exosome serves asthe perfect target for finding a biomarker that could enable early oral cancer detection by means of a simple saliva test.
Authors and Affiliations
Muy-Teck Teh
Keywords
Related Articles
- EP ID EP551978
- DOI 10.17140/DOJ-2-e002
- Views 160
- Downloads 0
A Rare Oral Focal Mucinosis Presentation in the Aesthetic Zone: A Case Report
The current case report presents a rare oral pathology of Oral Focal Mucinosis (OFM). The patient developed marginal gingival inflammation subsequent to esthetic crown lengthening surgery. The differential diagnosis incl...
Clinical Management of Regional Odontodysplasia
Here we present a case of a 7-year-old Japanese girl with regional odontodysplasia affecting tooth numbers 24, 25, 26, and 27. No other teeth were affected. Partially erupted tooth number 26 had a rough enamel surface an...
The Smile Solution: Smile! How to Make Yours Perfect
An esthetically pleasing smile is an attractive quality that lures people to you, making them immediatly respond positively to a first impression, before you’ve uttered a single word. The great news is that perfect smile...
Inverted Periosteal Technique – A Solution to Multiple Teeth Recession
Background: The periosteum being a highly cellular connective tissue also has a good regenerative potential. This quality makes it a suitable for use as autogenous graft. Here, is technique, the inverted periosteal techn...
Churro Jumper Arch: A Modified Approach to Improve Efficiency
In this clinical innovation the Churro jumper has been modified, by inserting it on an auxillary wire which is placed on the mandibular arch, instead of directly placing it on the main arch wire, to improve its efficienc...