Is there a Correlation between Micronutrients and Cognitive Status: An Exploratory Study of Senile Dementia of Alzheimer’s Type
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 4
Abstract
ABSTRACT Introduction: Alzheimer disease is a multifarious neurodegenerative disorder which is a leading cause of dementia in late adult life. It is characterised by deposition of intracellular neurofibrillary tangles and extracellular amyloidal protein which contributes to senile plaques. Studies suggested that vitamin B12 (cobalamin) and folate (folic acid) deficiency in the elderly are most common. These micronutrients are crucial for proper brain function and play an important role in mental and emotional health. Aim: To evaluate the level of homocysteine, folate, vitamin B12 and vitamin D in the serum of the patient suffering from Senile Dementia of Alzheimer’s Type (SDAT). Materials and Methods: The study was an open label, cross-sectional and comparative analysis. There were 110 patients suffering from SDAT taken as sample. Study included elderly patient aged 60-75 years and the duration of the study was 17 months (December 2014 to May 2016). The Group 1 (n=110, case) included patients whose age between 60-75 year given Treatment As Usual (TAU) and they were supplemented with oral vitamin B12 and folate during the treatment and Group 2 (n=55, control) included patients whose age between 60-75 year given TAU i.e., without any supplementation. The study was done by Competitive, sandwich Enzyme-linked Immune Sorbent Assay (ELISA) to assess the serum level of homocysteine, folate, vitamin B12 and vitamin D in patients suffering from SDAT (as cases) and healthy individual (as control). The statistical analysis was done by Student’s t-test. The data were expressed as mean±SD, p<0.05 was considered significant and mean±SD, p<0.001 was highly significant. Results: The mean serum homocysteine level was higher in cases (11.65±8) nm/mL as compared to controls (6.27±6.77) nm/mL. The mean value of serum homocysteine was found significant in cases as compared to controls (p<0.001). The serum folate (17.59±22.74 ng/mL/26.65±27.26 ng/mL), vitamin B12 (1.27±1.61 ng/mL/1.44±0.75 ng/mL) and vitamin D (21.01±34.68 ng/mL/42.74±70.49 ng/mL) level was lower in cases as compared to controls. The mean value of folate, vitamin B12and vitamin D was found to be not significant in cases as compared to controls (p>0.05). Conclusion: This study concluded that higher serum homocysteine levels, lower vitamin D, vitamin B12 and folate levels are risk factor for the SDAT.
Authors and Affiliations
Pooja Vashistha, kulsoom zahra, Ashok Kumar, Tapan Kumar, Mona Srivastava, Surendra Pratap Mishra
Keywords
Related Articles
- EP ID EP522291
- DOI 10.7860/JCDR/2018/32236.11376
- Views 26
- Downloads 0
Effect of Cycling on Glycaemia, Blood Pressure, and Weight in Young Individuals with Type 2 Diabete
Introduction: Aerobic exercise is associated with significant improvement in glycaemia and weight loss in Type 2 diabetes (T2D). Cycling, a form of aerobic exercise can benefit young (18 to <40 years) individuals with T2...
Right Psoas Abscess as a Consequence of Ruptured Appendix with Caecal Perforation and Presenting as Right Lumbar Swelling in a Toddler: A Rare Presentation of Appendicitis
ABSTRACT Psoas Abscess (PA) is a very rare form of presentation of appendicular pathology, especially in a toddler. A three-year-old male child presented to the casualty with complaint of right lumbar swelling for 14 day...
Management of Double Lip
Images in Medicine
Pericardial Haemangioma: A Common Tumour in an Unusual Location: Case Report and Review of Literature
Overall incidence of primary cardiac tumour ranges from 0.0017% and 0.27% at autopsy. Cardiac haemangiomas are rare, and account for 2.8% of benign cardiac tumours. Pericardial haemangiomas, in particular are extremely r...
Tuberculosis Vaccine Development: Current Status and Future Directions
Editorial