Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?
Journal Title: Turkish Journal of Osteoporosis - Year 2019, Vol 25, Issue 2
Abstract
Objective: Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an important biomarker for inflammation and endothelial dysfunction. It is important to assess carotid intima-media thickness (CIMT) in the evaluation of early atherosclerotic vascular diseases. In this study, we investigated this mechanism by measuring serum endocan levels and CIMT in patients with FMS and evaluated whether there is a correlation between them. Materials and Methods: Serum samples collected from 40 female patients diagnosed with FMS (the patient group) for the first time and 40 healthy female participants’ (the control group) endocan levels and CIMT ultrasonography were investigated, and the values of the two groups were compared. Results: Serum endocan levels and CIMT results were significantly higher in the patient group than in the control group (p<0.001). In addition, a very weak correlation was found between CIMT and endocan levels in patients with FMS. Conclusion: Increased subclinical inflammation, endothelial dysfunction, and early atherosclerosis play an important role in the pathophysiology of FMS. Increased endocan levels, CIMT, and the correlation between them will contribute to elucidating this mechanism.
Authors and Affiliations
Fatih Bağcıer, Fatih Hakan Tufanoğlu, Özgür Kadıçeşme
Keywords
Related Articles
- EP ID EP48781
- DOI 10.4274/tod.galenos.2019.16023
- Views 325
- Downloads 0
Fractures in Children with Spina Bifida
Objective: The aim of this study is to investigate the frequency of fractures and related factors in children with spina bifida who were followed up in our hospital. Materials and Methods: By retrospectively examination...
The Efficacy of Vitamin K2 in the Treatment of Pregnancy-associated Transient Osteoporosis of the Hip: A Case Report
Transient osteoporosis of hip is an uncommon, self-limiting clinical condition of unknown etiology characterized by an acute onset of hip pain, an antalgic gait and limited ranges of motion. Frequently this is followed b...
An Overview of the Musculoskeletal Comorbidity of Acromegaly: A Case with Non-traumatic Spontaneous Rectus Femoris Rupture
Acromegaly is a chronic endocrinopathy with pathologically increased levels of growth hormone (GH) and insulin-like growth factor-1 due to a pituitary adenoma that produces GH. One of the partially irreversible complicat...
Evaluation of Osteoporosis Awareness in Chronic Obstructive Pulmonary Disease Patients
Objective: Osteoporosis is a significant health problem that affects the quality of life negatively and places a serious burden on the national economy. The risk of osteoporosis in chronic obstructive pulmonary disease (...
Outcomes of Treatment in Patients with Severe Postmenopausal Osteoporosis: The Effects of Teriparatide Treatment on Bone Mineral Density, Back Pain and Biochemical Parameters
Objective: The aim of this study was to determine the effects of teriparatide treatment on bone mineral density (BMD), back pain, and biochemical parameters in patients with severe postmenopausal osteoporosis. Materials...