Is there correlation between the severity of upper gastrointestinal bleeding <br /> and Helicobacter pylori infection or the prior use of NSAIDs? <br /> <br />
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2004, Vol 21, Issue 3
Abstract
OBJECTIVE The incidence of Kaposi’s sarcoma (KS) in renal transplant recipients is significantly greater than that in the general population. It is still unclear whether post-transplant KS is due to reactivation of HHV-8 as result of immunosuppressive treatment or to primary HHV-8 infection transmitted via organ transplantation. The goals of the present study were assessment of the association of HHV-8 with KS developing in Greek renal transplant recipients and HHV-8 characterization, by subtyping of the ORF-26 and ORF-K1 genomic regions. METHOD Blood or tissue samples from transplant recipients with and without KS were examined. As controls, samples from classic KS patients, AIDS-associated KS patients and healthy individuals were examined in parallel. The ΗΗV-8 detection was performed by nested-PCR, and confirmed by nucleotide sequencing of the PCR products. The genotyping of HHV-8 isolates was carried out by nucleotide sequencing of specific variable regions of ORF-26 and ORF-K1. RESULTS Of 1055 patients who received renal transplants during the last 18 years, KS was encountered in 18 (1.7%). HHV-8 DNA was detected in 93.3% of KS transplant recipients and in 10% of transplant recipients without KS. HHV-8 DNA was found in all cases of patients with classic and AIDS-associated KS and in 16.7% of healthy individuals tested. Concerning the genotype, the findings imply a possible link with the C3 subtype of HHV-8 in renal-transplant related KS cases, a possible link with the A4 subtype in AIDS-associated KS cases and a potential involvement of the A1 subtype in Greek classic KS cases, as HHV-8 strains among healthy individuals tested belong to the C1, C3 or A1 subtypes. CONCLUSIONS Kaposi’s sarcoma presented with an incidence of 1.7% after renal transplantation in this study. A possible link with the C3 subtype of HHV-8 was identified in renal-transplant related KS cases.
Authors and Affiliations
G. ZAVOS, I. PAPAKONSTANTINOU, M. GAZOULI, V. METAXA-MARIATOU, P. ARAPANTONI-DADIOTI, K. GIASLAKIOTIS, A. KOSTAKIS
Keywords
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