Is Thiamine Administration Effective in Sepsis or Not? A Randomized Controlled Trial
Journal Title: International Journal Of Medical Science And Clinical Research Studies - Year 2022, Vol 2, Issue 12
Abstract
Background:Sepsis is the first leading cause of death in Myanmar and complications are also difficult to solve. This study aimed to detect the effect of thiamine on lactate clearance and mortality in patients with sepsis.Method:A randomized controlled trial done in No.(1) Defence Services General Hospital, Yangon from October 2020 to June 2022. All patients > 18 years old admitted with suspected or documented infection and qSOFA score 2 or 3 were included but alcohol related cases were excluded. Total 80 patients were assigned 1:1 by block randomization. Intervention group was given IV thiamine 100 mg 6 hourly for 3 days. Primary outcome was lactate clearance and secondary outcomes, mSOFA score (both were assessed in day 1, day 3 and day 7), and mortality within 7 days. Intention to treat analysis with worst data imputation in missing value for expired cases.Results:Significant lactate clearance was seen in intervention group compared with control group, in day 3, [23.53%(34.37) vs 16.67%(43.30), z = -2.353, p= 0.019]andday 7, [53.85%(28.90) vs 30.22%(38.61), z = -3.186, p= 0.001]. Lactate clearance over timewas well observedin the intervention group, [X2(2) = 29.356, p< 0.001] but not in the control group, [X2(2) = 3.152, p= 0.207]. Significant mSOFA scorereduction overtime was also observed in theintervention group, [X2(3) = 39.330, p< 0.001]. All-causemortality within 7 days was not different, [X2(1) = 0.949, p = 0.330, OR 0.949, 95% CI (0.51 –7.12)].Conclusion:Thiamine supplementation in sepsis patient wasbenefit in lactate clearance starting from day3 and reduction of mSOFA score starting from day 7. But it did not show the mortality benefit within 7 days period
Authors and Affiliations
Zar Ni Htet Aung, Nyan Lin Maung, Soe Win Hlaing, Soe Min Aung,Zaw Lin Thike, Win Min Tun, SaiAik Hla, Khin Ohnmar Kyaing, Khin Phyu Pyar
Keywords
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- EP ID EP738911
- DOI 10.47191/ijmscrs/v2-i12-33
- Views 4
- Downloads 0
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