Is Tocilizumab A Risk Factor for Lower Gastrointestinal Perforations? Isolated Cecal Necrosis: A Rare Case Report
Journal Title: Turkish Journal of Colorectal Disease - Year 2020, Vol 30, Issue 1
Abstract
Isolated cecal necrosis is a rare seen clinical condition. A 53-year-old woman with a history of rheumatoid arthritis and hypertension presented to the emergency room with complaints of abdominal pain and vomiting that persists for two days. She had been using tocilizumab (TCZ) for the last 5 months. Physical examination was compatible with acute abdomen. Abdomen computerized tomography showed a wall thickness approximately 3 cm on ascending colon that surrounded with significant inflammation. She was operated with a presumptive diagnosis of acute abdomen. During laparotomy, isolated necrosis with 10x9 cm diameter was observed in the cecum. A right hemicolectomy and ileocolostomy was performed. She was discharged on the 8th postoperative day. Postoperative specimen pathology was showed mucosal necrosis sharply separated from normal mucosal walls. Although the side effect profile of newly used drugs such as TCZ is not clear yet; with larger case reports and series can be contributed.
Authors and Affiliations
Emran Kuzey Avcı, Semra Demirli Atıcı, Sümeyye Ekmekçi, Can Arıcan, Tayfun Kaya, Cem Tuğmen
Keywords
Related Articles
- EP ID EP684926
- DOI 10.4274/tjcd.galenos.2019.2019-9-1
- Views 195
- Downloads 0
Intussusception Caused by an Appendiceal Mucocele: Case Report
Intussusception of the appendix in to the caecum caused by an appendiceal mucocele is a rarecondition. Acute appendicitis is the most common presentation is of the disease. Radiologic examination methods especially compu...
Penetrating Sharp Object Injury in the Gluteal Region and Small Bowel Perforation Due to Pelvic Penetration: A Case Report
Penetrating sharp object injuries in the gluteal region are common. However, it is very rare that these injuries lead to perforation of the small bowel by pelvic penetration, which is generally overlooked. As penetration...
Validity and Reliability of the Turkish Version of Pittman Ostomy Complication Severity Index
Aim: This study aimed to investigate the reliability and validity of the Turkish version of the Pittman Ostomy Complication Severity index. Method: This methodological research was carried out between January 1, 2017, a...
Evalution of the Patients with Colon Polyps in Terms of Helicobacter pylori with Sydney Criteria
Aim: Colorectal cancer (CRC) is one of the leading three cancers with high mortality. Colon polyps are precursors for CRC development. Helicobacter pylori is known to increase the risk of gastric cancer by intestinal met...
Perianal Methylene Blue Injection in Patient With Pruritus Ani Unresponsive To Medical Treatment: Video Presentation
Pruritus Ani is one of the common dermatological diseases of the perianal skin in the general population. This disease affects 1%-5% of the society. It presents as itching and burning in the perianal area. Men are affect...