Ischemic hepatitis: A severe concern
Journal Title: The Journal of Medical Research - Year 2017, Vol 3, Issue 3
Abstract
I read the review article by Waseem N and Chen PH (2016) about hypoxic hepatitis, also called ischemic hepatitis or shock liver [1] . The authors described the current concept, pathophysiology, clinical and anatomopathological features, diagnostic tools, and prevention and management of this ominous condition [1]. Ischemic hepatitis affects men at mean age of 64-70 years; the mortality rate is >50% [1-3] . The general incidence is 2 per 1000 patients, but in ICUs it may be up to 2.5 per 100 [1]. Diagnostic criteria include: cardiac, circulatory, or respiratory failure; dramatic transient rise of aminotransferase levels; and exclusion of other causes of liver cell necrosis [1-3]. The aminotransferase and lactate dehydrogenase levels typically peak within 24 hours, drop to nearly half values in 24 to 72 hours, and normalize between 1 to 2 weeks [1-3]. Liver biopsy can confirm the diagnosis in doubtful cases by demonstrating centrilobular necrosis [1-3]; however this procedure may be hazardous in presence of coagulopathy. Therapy directed to liver is unavailable, and one must correct predisposing factors [1-3].
Authors and Affiliations
Vitorino Modesto dos Santos
Keywords
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- EP ID EP442595
- DOI 10.31254/jmr.2017.3301
- Views 132
- Downloads 0
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