Isolation and Antimicrobial sensitivity pattern of Klebsiella pneumoniae from sputum samples in a tertiary care hospital
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2016, Vol 2, Issue 1
Abstract
Background: Gram negative pathogens are an important cause of community and hospital acquired infections throughout the world. Klebsiella pneumoniae has become one of the more common cause of these infections and one of the important aspects of Klebsiella associated infections is the emergence of multi-drug resistant strains particularly those involved in nosocomial diseases. This study was done to determine the isolation rate of Klebsiella, their antibiogram and for the presence of resistant strains from sputum samples. Materials & methods: A total number of 128 sputum samples were included in the present study. A total of 128 organisms were isolated, of them 30 (23%) were Klebsiella pneumoniae. Klebsiella were identified by standard microbiological techniques and antibiotic susceptibility testing was done by Kirby-Bauer disc diffusion method and interpreted as per CLSI guidelines. A total of 30 Klebsiella spp were isolated from 128 sputum samples, 100% were Klebsiella pneumoniae, sensitive to Amikacin (66%) Ciprofloxacin (68%), Gentamicin(62%), Cefepime (60%), Imipenem (56.66%), Aztreonam (52.63%). Isolates showed high resistance to Ticarcillin clavulanicacid (81%), Tobramycin (58%), Cotrimoxazole(50%). Results: The present study reveals the frequency of isolation of Klebsiella from sputum samples and their tendency towards antibiotic resistance. K. pneumoniae was found to be most sensitive to Amikacin, Gentamicin, Cefepime, Imipenem, Aztreonam and Ciprofloxacin. Females above 60 years of age are more affected and infections are more commonly associated with chronic obstructive pulmonary diseases and pneumonia. Conclusion: The data of this study may be used to determine trends in antimicrobial susceptibilities to formulate local antibiotic policies and overall to assist clinicians in the rational choice of antibiotic therapy
Authors and Affiliations
Shilpa. K1*, Ruby thomas2 , Allavarapu. Ramyashree3
Keywords
Related Articles
- EP ID EP582209
- DOI -
- Views 141
- Downloads 0
Myocardial infarction in pregnant women - A review
Introduction: Myocardial infraction is one of the most common causes of hospitalizing patients in industrial countries; in the US, 1.1 million people suffer from this disease, and about 30 percent of them die from the co...
Comprehensive study regarding intramedullary nailing in fractures of the femoral shaft
Introduction: Fractures of the shaft of the femur are among the most common fractures encountered in orthopaedic practice.Proximal & Distal femoral shaft fractures where one cannot get stable three point fixations with c...
The Effect of low Serum Vitamin D Levels on the Prevalence of Preeclampsia in Pregnant Women
As the most common metabolic disorder during pregnancy, diabetes causes chronic resistance to insulin through secreting extra volumes of insulin. Diabetes is a chronic disease which develops when pancreas does not produc...
Antibacterial activity of some Holy Plants
Medicinal plants are being used from earliest without knowing about their active elements. Herbs are occupied the top source of novel drug with antimicrobial activity. With reference to these points, the ethanolic extrac...
Diagnosis of Nodal Tubercluosis -by clinical and Histopathological correlation in pediatric age group (1-12 years)
Background: Cervical lymphadenopathy is a common clinical problem causing diagnostic dilemma. Various causes ranging from infections to autoimmune disorders are contributory. Hence it becomes essential to categorize them...