Isolation and identification of pharmacologically active compounds in fruit of Pyrus pashia
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 8
Abstract
The aim of this work is to investigate pharmacological active compounds analysis and their anti-inflammatory activity of Pyrus pashia fruit. In this work some pharmacological active compounds were isolated by column chromatographic techniques and identification of their structure by spectroscopic (NMR, IR, Mass, UV, etc.) methods. Lupeol, β-Sitosterol and β-Sitosterol –ß-D glucoside compounds were isolated. These compounds firstly were isolated from Pyrus pashia fruit. The anti-inflammatory activity of these compounds has been investigated with in vivo study. In this study, it has been shown that Pyrus pashia isolated compounds showed potent antiinflammatory activity. The active ingredient in the extract that reduces the inflammation is not known at present. There is ongoing research to isolate and characterize the bioactive compound (s) responsible for the antiinflammatory activity of Pyrus pashia.
Authors and Affiliations
Subhash Chandra| Department of Pharmaceutical Chemistry, H. N. B. Garhwal University (A Central University) Srinagar Garhwal Uttarakhand India Corresponding email- subhashkothiyal@gmail.com, Sarla Saklani| Department of Pharmaceutical Chemistry, H. N. B. Garhwal University (A Central University) Srinagar Garhwal Uttarakhand India, Rohit K. Agrawal| Department of Pharmaceutical Chemistry, H. N. B. Garhwal University (A Central University) Srinagar Garhwal Uttarakhand India
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