Isolation of Methicillin-resistant Staphylococcus aureus from Neonatal Sepsis at a Tertiary Care Hospital
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2019, Vol 6, Issue 10
Abstract
Introduction: Septicemia is the significant cause of morbidity and mortality in the neonates and is responsible for 30-50% of total neonatal deaths .Each year in developing countries. It is estimated that 20% of all neonates develop sepsis and approximately 1% die of sepsis related causes.In India, according to National Perinatal Database the incidence of neonatal septicemia has been reported to be 30/1000 live births. The emergence of methicillin resistant Staphylococcus aureus (MRSA) in neonatal patients is increasing. Early diagnosis and appropriate therapy of septicemia is of utmost importance to prevent morbidity and mortality. Aim and Study: It was to find out the bacteriological profile in neonatal sepsis and study their antimicrobial susceptibility pattern including detection of MRSA. Methods: This study was conducted for a period of one year in the department of microbiology in a tertiary care hospital. A total of 283 blood samples were collected using sterile precautions They were processed following standard laboratory protocol. Antibiogram was done using appropriate antibiotics by Kirby-Bauer disc diffusion method. Isolated of Staphylococcus aureus were tested for methicillin resistance. Results : Blood from 283 neonates with the clinical signs and symptoms of sepsis were collected and samples were processed. Out of which 96 (33.92%) were culture positive.Total 53 (55.2%) Staphylococcus aureus were isolated out of which 27 (50.94%) were MRSA (Methicliin Resistant Staphylococcus aureus).Acinetobacter spp.was isolated in 15 (15.62%) cases.Klebsiella spp. was isolated in 13 (13.54%) cases. Psedomonas spp. was isolated in 3(3.12%) case . Antibiotic sensitivity test of MRSA was done and all MRSA isolates were sensitive to Vancomycin. Conclusion: Multidrug resistance among the isolates was common. Early diagnosis and institution of specific antibiotics after studying the sensitivity pattern will help in reducing neonatal morbidity and mortality and prevent emergence of drug resistant strains. An effective infection-control programme, regular antibiotic susceptibility surveillance ,evaluation, and the enforcement and periodic review of the antibiotic policy of the hospital as well as the encouragement of rational antibiotic use will reduce the rates of development of bacterial resistance.
Authors and Affiliations
Sudhir Singh, Sumit Kumar, Pallavi Kumari
Keywords
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