Isolation of Principle Active Compound of Acorus Calamus. In Vivo Assessment of Pharmacological Activity in the Treatment of Neurobiological Disorder (Stress)
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 9
Abstract
Acorus calamus (Araceae) is a plant widely used as food and medicine worldwide but isolation of principle active compound from hydroalcoholic extract and antistress activity compound is not reported. Dried and powder rhizome of Acorus calamus (Araceae) was used to isolate the chemical constituent using phase column chromatography and TLC purification. Structure was elucidated by spectroscopic methods. Elevated plus maze (EPM) model and forced swimming test (FST) were performed to assess antistress activity on albino mice. (Doses of the isolated chemical constituents: 25, 50 and 100 mg/kg orally) The crude hydroalcoholic extract of Acorus calamus (Araceae) was successively partitioned with n-hexane-EtOAc. The structure of the compound was determined by spectroscopic analysis. The results of elevated plus maze (EPM) model and forced swimming test (FST) revealed that isolated compound having antistress activity. This is the first report of antistress activity of β-Asarone and isolation by column chromatography separation, and TLC purification. The result also revealed that β-Asarone is a potent compound for the treatment of neurobiological disorder (stress). This compound may account for the use of Acorus calamus in folk medicine to treat the stress.
Authors and Affiliations
Neha Tiwari
Keywords
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