Isolation of Respiratory Pathogens and Antibiotic Sensitivity Study in Clinical Samples of Patients Attending Tertiary Care Hospital, Tirupati
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Lower Respiratory Tract Infection (LRTI) is one of the leading causes of morbidity and mortality globally. Present study was undertaken to isolate etiological agents and study their antibiotic sensitivity pattern. The study was carried out to isolate and identify the common bacteria causing lower respiratory tract infections among patients attending to S.V.R.G.G. Hospital, Tirupati from January to December, 2014. Specimens coming to the laboratory were processed by standard laboratory procedures. From a total number of 548 sputum samples processed, culture negative for pathogenic organisms 170 in number, no bacterial growth seen in 22 and Candida species isolated from 50 samples were excluded from our study. Out of total 548 samples, the pathogens identified were 306 (55.8%). Males were found to be more in number, 176 (57.5%) than females, 130 (42.5%). Pathogenic organisms isolated were Streptococcus pneumoniae 124 (40.5%), Klebsiella pnuemoniae 98 (32%), Staphylococcus aureus 34 (11.1%), Esch. coli 17 (5.6%), Pseudomonas aeruginosa 17 (5.6%), Moraxella species 10 (3.3%), Acinetobacter species 5 (1.6%) and Proteus mirabilis 1 (0.3%). Antibiotic sensitivity testing was done for all 306 pathogenic isolates. Antibiotic discs used were amikacin, cotrimoxazole, ceftriaxone, ceftazidime, ciprofloxacin, gentamicin, levofloxacin and piperacillin/tazobactam. Carbenicillin was used for Pseudomonas species, ampicillin and amoxicillin were added for Gram positive organisms, vancomycin and imipenem for resistant isolates. As per present study in lower respiratory tract infections, the predominant species isolated was Streptococcus pneumoniae followed by Klbesiella pneumoniae. In view of emergence of drug resistant organisms, judicious use of antibiotics is to be advocated and followed up to bring down the morbidity and mortality specially due to lower respiratory tract infections being the commonest and an alert is given for the dire necessity of antibiotic policy.
Authors and Affiliations
Dr. Shodavaram Usha Vidya Rani, Dr. Mallajosyula Venkata Ramanamma, Dr. Arava Lazarus Mukherjee, Er. Akkarapakam Suneesh Jacob
Keywords
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