Isolation of the Rare Opportunistic Yeast Saprochaete capitata from Clinical Samples-Experience from a Tertiary Care Hospital in Southern India and a Brief Review of the Literature
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 9
Abstract
Introduction: Saprochaete capitata (Teleomorph: Magnusiomyces capitatus) is a ubiquitous yeast found in environmental sources such as soil, water, air, plants and dairy products. It is also a part of the normal microbial flora in humans. The yeast is being increasingly reported as an opportunistic pathogen, especially in patients in the haemato-oncology setting, the infection being often mistakenly diagnosed as invasive candidiasis. Aim: To review the epidemiological, clinical and microbiological features of six patients admitted in our hospital over a period of 10 years (from January 2007 to December 2016), from whom Saprochaete capitata was isolated. Materials and Methods: A retrospective study was conducted and the epidemiological, clinical, imaging and microbiological data of the six patients were collected and analysed. Results: The age of the six patients ranged from 19 years to 65 years with a median age of 53 years. There were two males and four females. In three out of the six patients, the isolation of S. capitata was considered clinically significant as the yeast was isolated repeatedly from blood and/or respiratory specimens and the clinical features could not be explained by any other alternative diagnosis. Haematological malignancy was the underlying disease in three out of the six patients while one patient was on triple immunosuppression following renal transplantation four years back. Three out of the six patients had severe neutropenia with Absolute Neutrophil Count (ANC) ≤ 500 at the time of isolation of S. capitata. Two patients with clinical features of fungal sepsis received antifungal therapy with Amphotericin B but succumbed within a short period of starting the therapy. The post renal transplant patient who presented with pneumonia recovered after treatment with a combination of Amphotericin B and Voriconazole. Conclusion: Awareness regarding the epidemiological, clinical and microbiological aspects of invasive infections caused by S. capitata is essential for early recognition and appropriate management.
Authors and Affiliations
Umabala Pamidimukkala, Anuradha Kancharla, Sukanya Sudhaharan, Sadashivudu Gundeti, Surendra Mandarap, Vamsi Krishna Nagalla, Sree Bhushan Raju, Sandhya Devi Karanam
Keywords
Related Articles
- EP ID EP362710
- DOI 10.7860/JCDR/2017/30339.10669
- Views 75
- Downloads 0
Arm Function and Quality of Life Among Patients after Mastectomy
ABSTRACT Introduction: For many women with breast cancer, mastectomy is a common form of treatment which has an indirect effect on female beauty, sexuality and feminity. Also, the patients suffer severe arm and shoulder...
A Study on the Knowledge, Attitude and Practices Regarding Menstrual Hygiene among Adolescent Girls in Schools in a Rural Area of Goa
ABSTRACT Introduction: Menstruation is a natural physiological process surrounded by myths and taboos which often lead to misconceptions and faulty knowledge and practices in menstruation. Along with social and cultural...
Spectrophotometric Evaluation of Colour Stability of Nano Hybrid Composite Resin in Commonly Used Food Colourants in Asian Countries
Introduction: There is growing interest in colour stability of aesthetic restorations. So far few studies have been reported. Aim: This study was designed to investigate the effects of different common food colourants i....
Maxillary Second Molar with Fused Root and Six Canals- A Case Report
One of the known aberrations in root canal morphology of maxillary second permanent molars is the presence of collateral mesiobuccal canals. This case report describes the endodontic management of a maxillary second mola...
Clinical Profile, Evaluation and Management of Gallstone Disease in Children in a Rural Referral Tertiary Centre
ABSTRACT Introduction: Cholelithiasis or gallstone disease is primarily a disease of adults. Recently, there has been a global increase in the incidence in children resulting in an increased number of cholecystectomies b...