IVF Outcomes of Microdose Flare-up, GnRH Antagonist and Long Protocols in Patients Having a Poor Ovarian Response in the First Treatment Cycle
Journal Title: Journal of Surgery Research and Practice - Year 2021, Vol 2, Issue 1
Abstract
Objectives: To compare the outcome of patients assumed to be poor responders before their first cycle of IVF and treated either microdose flare-up or GnRH antagonist protocols with patients stimulated by long GnRH protocol and had a poor ovarian response with a low yield of the oocyte after their first IVF cycle. Study Design: Retrospective cohort study. Place and Duration of Study: Department of Obstetrics and Gynecology from September 2014 to February 2019. Methodology: Patients treated with the first cycle of IVF and diagnosed as poor responders after ovarian stimulation were evaluated according to the treatment protocol, including microdose flare-up (Group 1: 136 patients), GnRH antagonist (Group 2: 105 patients), and long GnRH agonist (Group 3: 77 patients). Results: Basal FSH level was significantly lower in group 3 compared to other groups (p<0.05). The number of oocytes retrieved, the number of metaphase II oocytes were similar between groups, although the mean AFC was significantly higher in group 3 than in group1 and 2 (p<0.05). Clinical pregnancy rates per patient were higher in group 3 (22.9%) than in group 1 (13.7%) and group 2 (14.4%), but the difference was not statistically significant (p=0.214). The live birth rate per patient was statistically higher in group 3 (21.4%) as compared to other groups (9.7%, 10.3%, respectively; p<0.05). Conclusion: Long protocol may be an option in poor responders undergoing IVF. Ovarian reserve markers are essential factors with stimulation protocol for the success of IVF in poor responder patients.
Authors and Affiliations
Hassan Mumtaz*, Shahzaib Ahmad, Farrukh Zaman, Aamir Ghazanfar
Keywords
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- EP ID EP698905
- DOI http://dx.doi.org/10.46889/JSRP.2021.2107
- Views 67
- Downloads 0
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