JAK inhibitors: Evolving therapies in rheumatoid arthritis
Journal Title: IP International Journal of Orthopaedic Rheumatology - Year 2018, Vol 4, Issue 2
Abstract
In rheumatoid arthritis there has been a paradigm shift from controlling symptoms to controlling the disease progress with abrogation of inflammation Achieving this remission or very low disease activity has become increasingly possible with USA FDA approved first JAK inhibitor Tofacitinib in November 2012 not in Europe This new small molecule JAK inhibitors are oral drug working intracellularly in comparison to TNF inhibitors targeting a singly cytokine within extracellular space confining themselves to cell surface receptors The second JAK inhibitor Baracitinib approved in Europe in February 2017 and in USA in May 2018 has greater promises Once daily 2 mg oral dose used either as monotherapy or in combination with methotrexate in moderate to severe active rheumatoid arthritis in adults have provided remission even in patients who have responded inadequately or are intolerant to one or more DMARDs bDMARDs It is a safe second line therapy after methotrexate In DMARD nave patients it is likely to become firstline agentsKeywords JAK inhibitor TNF inhibitor NSAID bDMARD Methotrexate Tofacitinib
Authors and Affiliations
Shiva Shankar Jha
Keywords
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- EP ID EP486040
- DOI 10.18231/2455-6777.2018.0011
- Views 74
- Downloads 0
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