Journal of Contemporary Medical Research Volume 4 | Issue 1 | January 2017 | ICV (2015): 77.83 | ISSN (Online): 2393-915X; (Print): 2454-7379 110 Efficacy of Autologous Serum Therapy in Chronic Urticaria
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Chronic urticaria is a common and distressing dermatosis and patients were subjected to high pill burden. Autohemotherapy was regarded as potentially curative therapeutic option in chronic urticaria especially in autoreactive group. Later this procedure was refined by using autologous serum instead of whole blood. The aim of this study was to find out proportion of ASST positive patients among chronic urticaria patients and efficacy of Autologous Serum Therapy (AST) in both ASST positive and negative groups. material and Methods: A total of 50 were enrolled into study. Autologous Serum Skin Test (ASST) was done in all patients. In both ASST positive and negative patients, Autologous Serum injections were given weekly for 9 weeks. The effect of AST was recorded by using Urticaria Total Severity Scale at every visit. Patients were followed up for 12 weeks after 9 weekly Autologous serum injections. Results: A total of 50 patients were enrolled into study. ASST positive group consists of 29 patients and ASST negative group consists of 21 patients. Symptoms of urticaria showed reduction from 4th week of AST in both ASST positive and negative patients. Antihistamine usage declined from 100% baseline in both groups to 37.3% and 57.1% in ASST (+) and ASST (–) groups respectively. At 21 wks, 37.9% of ASST (+) group and 23.8% of ASST (–) group showed complete clearance. Conclusion: We found that AST prove to be better treatment modality with less side effects to reduce pill burden irrespective of autoimmune nature of urticaria
Authors and Affiliations
S Nageswaramma, V. lakshmi Sarojini, B. Bhavani Pujitha, G. Sirisha, G. Suma Bindu
Keywords
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