K-ras gene mutation as an early prognostic marker of colon cance
Journal Title: Polish Journal of Surgery - Year 2016, Vol 88, Issue 1
Abstract
Due to increased colorectal cancer incidence there is a necessity of seeking new both prognostic and prediction factors that will allow to evolve new diagnostic tests. K-ras gene seems to be such a factor and its mutations are considered to be an early marker of progression of colorectal cancer. The aim of the study was to find a correlation between K-ras gene mutation in patients with diagnosed colorectal cancer and selected clinical parameters. Material and methods. A total of 104 patients (41 women and 63 men) with diagnosed colorectal cancer were included in this study. The average age of male group was 68.3 and in female group – 65.9. Samples were taken from paraffine blocks with tissue from diagnosed patients and K-ras gene mutation were identified. Afterwards the statistical analysis was made seeking the correlation betweenK-ras gene mutation incidence and clinical TNM staging system, tumour localisation, histological type, sex, age. Results. K-ras gene mutations were detected in 20.1% of all colorectal cancers. Significantly higher rate of K-ras gene mutations were diagnosed among patients classified at stage I (40%), stage IIC (50%) and stage IV (50%) according to the TNM classification. Conclusions. The results of our study are compatible with other studies and indicate the correlation between K-ras gene mutation and colorectal cancer incidence. Identification of K-ras gene mutation may complement other diagnostic methods at early stage of colorectal cancer.
Authors and Affiliations
Łukasz Szpon, Aleksander Stal, Marcin Zawadzki, Anna Lis-Nawara, Wojciech Kielan, Zugmunt Grzebieniak, Zygmunt Grzebiak
Keywords
Related Articles
- EP ID EP77197
- DOI -
- Views 151
- Downloads 0
Choroba IgG4 zależna manifestująca się jako izolowana zmiana w obrębie żołądka– przegląd literatury
Wstęp: Choroba IgG4 zależna (IgG4-RD) jest niedawno opisaną jednostką chorobową o nieustalonej etiologii i patogenezie, charakteryzującą się występowaniem bogatych w komórki IgG4 dodatnie nacieków tkankowych z włóknienie...
Zakażenia miejsca operowanego – przegląd aktualnej wiedzy, metody zapobiegania
Wstęp: Infekcje miejsca operowanego (ang. <i>Surgical site infections </i>– SSI) towarzyszą ludzkości od zarania dziejów. Wraz z rozwojem medycyny udało się zmniejszyć ich odsetek, jednak do dziś stanowią poważny problem...
Intraoperative neuromonitoring of hypogastric plexus branches during surgery for rectal cancer – preliminary report
Aim: The aim of this study was to present our preliminary experience with intraoperative neuromonitoring during rectal resection. Materials and methods: We qualified 4 patients (2 women, 2 men; age 42 – 53 years) with re...
Retroperitoneal abscess with retained gall-stones as a late complication of laparoscopic cholecystectomy
Laparoscopic cholecystectomy is the golden standard, considering treatment of cholelithiasis. During the laparoscopic procedure one may often observe damage to the gall-bladder wall, as well as presence of gall-stones in...
Risk factors and inflammatory predictors for Anastomotic Leakage following Total Mesorectal Excision with defunctioning stoma
Background: This study aims to examine the factors involved in anastomotic leak (AL) following low anterior resection and total mesorectal excision (LAR-TME) and to determine the usefulness of early measurement of the in...