KARIOMETRIJSKA ANALIZA SKVAMOZNE METAPLAZIJE, DISPLAZIJE I PLANOCELULARNOG KARCINOMA PLUĆA
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 3
Abstract
Sekvence prekursornih lezija planocelularnog karcinoma mogu biti hiperplazija-metaplazija-displazija-karcinom in situ. Cilj rada bio je da se izvrši kariometrijska analiza skvamozne metaplazije, displazije umerenog gradusa i planocelularnog karcinoma pluća. Analizirane su bronhoskopske biopsije normalne mukoze kod bolesnika sa hroničnim bronhitisom (n=10), skvamoznom metaplazijom (n=10), umerenom displazijom (n=11), planocelularnim karcinomom (n=48) i "na izgled normalnom” mukozom u okolini karcinoma (n=11). Ispitivana su tri nuklearna parametra uz pomoć sistema za analizu prikaza. Prosečni ekvivalentni nuklearni dijametar, area i volumen ekvivalentne sfere planocelularnog karcinoma bili su signifikantno veći nego kod umerene displazije, skvamozne metaplazije i normalne bronhijalne mukoze. Vrednosti ekvivalentnog dijametra, areala i volumena ekvivalentne sfere jedara bili su signifikantno veći u “na izgled normalnoj” mukozi kod bolesnika sa planocelularnim karcinomom u odnosu na normalnu mukozu kod bolesnika sa hroničnim bronhitisom. Kariometrijska analiza može biti korisna pomoćna metoda u diferenciranju planocelularnog karcinoma od displazije i displazije od skvamozne metaplazije na bronhoskopskim biopsijskim uzorcima.
Authors and Affiliations
Žaklina Mijović, Zoran Pešić, Nikola Živković, Tijana Denčić, Ana Ristić Petrović, Slavica Stojnev
Keywords
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- EP ID EP121694
- DOI 10.2478/afmnai-2014-0022
- Views 98
- Downloads 0
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