Karyomegalic tubulointerstitial nephritis: A rare cause of chronic kidney disease
Journal Title: Nephro-Urology Monthly - Year 2011, Vol 3, Issue 3
Abstract
Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology with typical clinical features of slowly progressive renal failure in the third decade of life. Histological findings characterize striking enlarged and hyperchromic nuclei in numerous tubular epithelial cells throughout the nephron accompanied by interstitial fibrosis around atrophic tubules. Herein, we report a case of 30 year-old patient who presented with asymptomatic progressive renal dysfunction in 2009. Renal biopsy revealed chronic tubulointerstitial nephritis and an unusually marked karyomegaly particularly of the tubular epithelium.
Authors and Affiliations
Ebru Uz, Yeter Bayram, Hacer Haltas, Nuket Bavbek, Mehmet Kanbay, Galip Guz, Ali Akçay
Keywords
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