Ki-67 Expression in Premalignant and Malignant lesions of Gallbladder
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Introduction: Cell proliferation is an important pre-requisite for the development of a neoplasm. Ki-67 is one of the most important cell proliferation markers. Its expression is correlated with the aggression of various histopathologic changes in the epithelium of gallbladder. Aim: The aim of this study to assess the expression of Ki-67 in various pathological lesions of gallbladder. In the study immunohistochemical expression of Ki-67 was evaluated. Material and Methods: This case control study included 154 patients who underwent cholecystectomy for various reasons like carcinoma and cholelithiasis. Out of 154 patients of gall bladder which included 85 cases of malignant lesion (adenocarcinoma) and 47 cases of premalignant and premalignant like lesions (including dysplasia, metaplasia, and xanthogranulomatous cholecystitis) along with 22 cases of chronic cholecystitis as control. Results: The result showed Ki-67 Li in malignant group, a total of 14 (16.5%) patients had Ki-67 Li expression in range 10-25% and remaining 7 (8.2%) had Ki-67 Li expression >25%. The Ki-67 Li expression was higher for patients aged >40 years, females, with well/ moderately differentiated adenocarcinoma and tumor diameter <2 cm. Conclusion: The conclusion can be made that Ki-67 can be used as a marker of aggression of gall bladder histopatholgic lesions.
Authors and Affiliations
Dr. Ajay Kr. Singh
Keywords
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