Kidney Ischemia and Reperfusion Injury – Field of Glory or Warterloo for Erythropoietin?
Journal Title: Nephrology – Open Journal - Year 2016, Vol 1, Issue 3
Abstract
When asking clinicians about their knowledge about Erythropoietin (EPO) most of them would say that it increases Red Blood Cell (RBC) count and can therefore be used to treat anemia, is produced in the kidneys and can be misused as doping agent in sports. The way to reach this today’s common knowledge was long and hard. In the year 1667 by giving a lambs blood to an anemic patient and the lucky outcome that the patient felt better afterwards, it became clear that blood could heal.1 Over two centuries later in a rabbit experimental set-up where plasma was transduced between an anemic and a healthy animal it could be seen that the red blood cell count increased in the anemic one. This gave birth to the thesis that a humeral factor is responsible and was named hemopoietin.2 Seventy years later this mysterious substance was found by Goldwasser in patients´ urine3 and was later on cloned by a colleague of him4 what marked the beginning of EPOs therapeutic career in treating anemia that lasts on until today.
Authors and Affiliations
Florian Simon
Keywords
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- EP ID EP558176
- DOI 10.17140/NPOJ-1-e004
- Views 192
- Downloads 0
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