Killer Cell Immunoglobulin-Like Receptor Genes Polymorphisms in Macedonian Patients with Haematological Malignancies
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2013, Vol 6, Issue 1
Abstract
Aim: The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes (KIR2DL1,KIR2DL2,KIR2DL3,KIR2DL4,KIR2DL5,KIR3DL1,KIR3DL2,KIR3DL3,KIR2DS1,KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DS1, KIR2DP1, and KIR3DP1) and KIR genotypes in Macedonian patients with haematological malignancies, to compare them with the corresponding frequencies of healthy Macedonians and to analyse eventual association of specific genes or genotypes with the studied haematological diseases. Material and Methods: The study included 63 patients of which 40 had acute myeloblastic leukaemia (63.5%), 11 (17.5%) had chronic myeloid leukaemia, 8 (12.7%) acute lymphoblastic leukaemia, 2 (3.17%) non-Hodgkin Lymphoma, 1 (1.59%) aplastic anemia, and 1 (1.59%) chronic lymphocytic leukaemia. Results: Comparison of KIR gene frequencies between the 63 patients and healthy Macedonians reveals statistically significant difference for KIR3DL2 (F= 1 in the control group, and 0.95 in the patients group, p=0.001). Another statistically significant difference was observed for the frequency of Bx3 and Bx439 genotypes both found more often in patients group (P=0.017 and P= 0.009, respectively). Conclusion: Further analysis, involving larger series of patients and targeted at the ligands of the KIRs are needed in order to determine a certain KIR gene and/or genotype as either predisposing, or protecting factor for haematological malignancy in patients from Republic of Macedonia.
Authors and Affiliations
Aleksandar Petlichkovski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia, Zlate Stojanoski| University Clinic of Haematological Diseases, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia, Dragan Cibrev| Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia, Mirko Spiroski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia
Keywords
Related Articles
- EP ID EP8902
- DOI 10.3889/MJMS.1857-5773.2012.0271
- Views 290
- Downloads 14
Macedonian International Medical Publications Indexed in PubMed in 2010
We present abstracts of published papers in international journals deposited in PubMed between 2010- 01-01 and 2010-12-31 from the scientists affilited in institutions from the Republic of Macedonia [(Macedonia[Affilia...
Evaluation of Iron Status in Relation to Feeding Practices in Early Infancy
Despite the Turkish government mandate to educate every new mother about the advantages of breastfeeding and pre- and perinatal nutrition programs, the prevalence of both iron deficiency (ID) and iron deficiency anemia...
Macedonian Medical Master of Science Theses in Public Health Defended in 2007-2010
We present English abstracts of MSc theses in Public Health defended in 2007-2010 at the Faculty of Medicine, University “Ss Cyril and Methodiusâ€, Skopje, Republic of Macedonia. English summaries are published as t...
Ocimum Gratissimum Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats
Aim: Hepatoprotective effects of Ethanolic extract Ocimum gratissimum leaves (O. gratissimum) in streptozotocin-induced diabetic rats was studied. Material and Methods: Thirty-six adult rats were assigned into six grou...
Intravenous Iron Is Effective and Safe in Correcting Anemia in Erythropoietin-Treated Hemodialysis Patients
Objectives: To study the effect of intravenous iron in the management of anemia in erythropoietin (EPO) treated hemodialysis patients with poor response to treatment with oral iron. Methods: Thirty-six patients (27 men...