Killer cell immunoglobulin like receptors gene polymorphism in patients with dengue infection, Andaman Islands, India
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2015, Vol 5, Issue 1
Abstract
Objective: To identify the possible association of killer cell immunoglobulin like receptors (KIRs) gene polymorphisms in patients with dengue virus infection. Methods: Seventeen known KIRs were determined in 30 dengue patients and 40 healthy individuals by the sequence specific primer polymerase chain reaction method. Associations with specific KIR genes were tested using the Chi-squared test and Fisher test using EpiInfo 7 software. Results: All frame work genes and pseudo genes were detected among 97% and 98% of all dengue cases and healthy individuals respectively. The total carriage frequency of KIR3DL1 and KIR2DL2 were decrease in dengue patients compared with healthy individuals (P=0.000 0 and P=0.000 5 respectively) from A haplotype and inhibitory receptors. Conclusions: The KIR polymorphisms may be associated with susceptibility to dengue virus infection. It could be suggested that KIR3DL1 and KIR2DL2 were susceptibility genes for dengue virus. However, these findings provide certain support for hypothesis, that KIR genes influence susceptibility and may play a role in the clearance of dengue virus infection.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP227060
- DOI 10.1016/S2222-1808(14)60625-3
- Views 100
- Downloads 0
In silico molecular modeling of neuraminidase enzyme H1N1 avian influenza virus and docking with zanamivir ligands
Objective: Neuraminidase is an enzyme aspartic protease that is essential for the life cycle of H1N1. Methods: Constructed a model of Neuraminidase enzyme the 3D structure as template using with Modeller software. The Ne...
Larvicidal efficacy of Ocimum basilicum extracts and its synergistic effect with neonicotinoid in the management of Anopheles stephensi
Objective: To evaluate the larvicidal activities of different combinations of synthetic nicotinoid insecticide, imidacloprid with an insecticidal plant, Ocimum basilicum (O. basilicum) against malaria vector, Anopheles s...
Neurological manifestations in HIV positive patients in Tehran, Iran
Objective: To evaluate the neurological complications among Iranian HIV-positive patients. Methods: This cross-sectional study was conducted among 428 patients diagnosed with HIV infection between 2006 and 2009 at Imam K...
In vitro and in vivo protocols of antimicrobial bioassay of medicinal herbal extracts: A review
Antimicrobial susceptibility testing against pathogenic microorganisms is the most significant task of clinical microbiology laboratory. The present study was therefore designed to review the in vitro and in vivo protoco...
Seroprevalence of Toxoplasma among HIV infected and HIV non-infected individuals in North India
Objective: To determine the seroprevalence of Toxoplasma infection in the HIV infected and HIV non-infected individuals in our region, including antenatal women. Methods: Five mL of blood sample was collected from a tota...