KIMURA’S DISEASE- CLINICO / HISTOPATHOLOGICAL STUDY IN HEAD AND NECK REGION
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 43
Abstract
BACKGROUND Kimura’s disease is a rare chronic inflammatory condition of unknown aetiology which has been most commonly reported in Asian population, with young male preponderance. It is a benign disease which has an indolent course & gradually increases in size over months or years. It primarily involves the head and neck region, presents as subcutaneous masses and is often accompanied by regional lymphadenopathy, salivary gland involvement along with lymphadenopathy or presents with only lymphadenopathy. Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features. Microscopy reveals lymphoid proliferation with eosinophilic infiltration. For years, Kimura’s disease was believed to be identical to or part of the same disease spectrum as angiolymphoid hyperplasia with eosinophilia (ALHE). Recent reports, however, have confirmed that the two are, in fact, separate entities. MATERIALS AND METHODS It was a retrospective study undertaken over a period of one year from November 2016 to November 2017 in the Department of Pathology, Government ENT Hospital, Hyderabad. We report a study of eight (8) cases of Kimura’s disease with usual and unusual sites of presentation and rare histomorphological features / microscopic features in one of the cases. Initially FNAC was performed with 22 gauge needle; smears were fixed in ether- 95% alcohol solution and stained with Haematoxylin and Eosin stain, whereas air dried smears stained with toluidine blue stain. Subsequently excised specimens of those swellings and lymph nodes received were subjected to routine processing, cutting, staining and histopathological features were analysed. Haemogram, serum IgE levels and renal parameters of all these patients were studied. RESULTS Both cytomorphological and histomorphological features were in favour of Kimura’s disease. CONCLUSION We report characteristic cytomorphological and histomorphological findings associated with peripheral eosinophilia and elevated serum IgE levels in eight patients with Kimura's disease.
Authors and Affiliations
Shrinivas Bheemrao Somalwar, Padmamalini K. , Madhavi Parigi, Shravan Kumar O.
Keywords
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- EP ID EP598935
- DOI 10.18410/jebmh/2018/610
- Views 87
- Downloads 0
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