Kinetic Modelling for the Assay of Nortriptyline Hydrochloride Using Potassium Permanganate as Oxidant
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 3
Abstract
Kinetic methods for accurate determination of nortriptyline hydrochloride have been described. The methods are based on the oxidation of nortriptyline hydrochloride with KMnO4 in acidic and basic media. In acidic medium, the decrease in absorbance at 525.5 nm and in basic medium, the increase in absorbance at 608.5 nm were measured as a function of time. The variables affecting the reactions were carefully investigated and optimised. Kinetic models such as initial rate, rate constant, variable time and fixed time were employed to construct the calibration curves. The initial rate and fixed time methods were selected for quantification of nortriptyline hydrochloride. In acidic medium, the calibration curves showed a linear response over the concentration range 10–50 μg mL−1 for initial rate and 10–60 μg mL−1 for fixed time method (2 min). In basic medium, the calibration graphs were linear over the concentration range 10–100 μg mL−1 for initial rate and fixed time methods (4 min). In acidic medium, the limits of detection for initial rate and fixed time methods (2 min) were 1.02 and 3.26 μg mL−1, respectively. In basic medium, the limits of detection were found to be 1.67 and 1.55 μg mL−1 for initial rate and fixed time methods (4 min), respectively. The initial rate and fixed time methods have been successfully applied to the determination of nortriptyline hydrochloride in commercial dosage form. Statistical comparison of the results of the proposed methods with those of reference method exhibited excellent agreement and there is no significant difference between the compared methods in terms of accuracy and precision.
Authors and Affiliations
Nafisur Rahman, Sumaiya Khan
Keywords
Related Articles
- EP ID EP682236
- DOI 10.1208/s12249-014-0230-8
- Views 92
- Downloads 0
Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats
The online version of this article (doi:10.1208/s12249-014-0206-8) contains supplementary material, which is available to authorized users.
Development of Modified-Release Tablets of Zolpidem Tartrate by Biphasic Quick/Slow Delivery System
Zolpidem tartrate is a non-benzodiazepine analogue of imidazopyridine of sedative and hypnotic category. It has a short half-life with usual dosage regimen being 5 mg, two times a day, or 10 mg, once daily. The duration...
Erratum to: Potential of Piperazinylalkylester Prodrugs of 6-Methoxy-2-Naphthylacetic Acid (6-MNA) for Percutaneous Drug Delivery
The online version of the original article can be found at 10.1208/s12249-014-0240-6.
Devices for Dry Powder Drug Delivery to the Lung
Dry powder inhalers (DPIs) are an important and increasingly investigated method of modern therapy for a growing number of respiratory diseases. DPIs are a promising option for certain patient populations, and may help t...
Considerations for a Pediatric Biopharmaceutics Classification System (BCS): Application to Five Drugs
It has been advocated that biopharmaceutic risk assessment should be conducted early in pediatric product development and synchronized with the adult product development program. However, we are unaware of efforts to cla...