KRAS, EGFR AND PIK3CA mutation in triple negative breast carcinomas
Journal Title: International Journal of Medical Research & Health Sciences - Year 2016, Vol 5, Issue 3
Abstract
Triple negative breast carcinoma is defined by the absence of oestrogen receptor (ER) and progesterone receptor (PR) expression and the lack of HER2 gene amplification. It comprise 10-17 % of all breast cancers. Though EGFR gene mutaion is rare in triple negative breast cancers, 47-70 % expressed EGFR protein. PIK3CA mutation is a frequent event in breast cancers. We aim to investigate EGFR, KRAS and PIK3CA mutation in triple negative breast carcinomas by pyrosequencing and compare the results with hormone receptor positive and HER2 overexpressed breast carcinomas which were identified by immunohistochemistry. No mutations in Exon 18, 19, 20 and 21 of EGFR gene were detected in all groups. KRAS mutation was identified in only one case. PIK3CA mutations were detected in 9 of TNBC ( 23.7 %), 5 of hormone receptors positive, HER2-negative tumors (50 %) In HER2-positive tumors, no mutations were detected in PIK3CA gene. Our results revealed that PIK3CA inhibitors might be a new candidate in the targeted treatment of triple negative breast cancers that were resistant to chemotherpy. Theseresults should be supported by large series with survival analysis.
Authors and Affiliations
Erdoğan G
Keywords
Related Articles
- EP ID EP247582
- DOI -
- Views 84
- Downloads 0
Determinants of lost to follow up during treatment among tuberculosis patients in Delhi
Tuberculosis ranks as the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus. With more than two million cases of tuberculosis, India remains on top in the list of...
The effect of Carica papaya leaves extract capsules on platelets count and hematocrit levels in acute febrile illness with thrombocytopenia patient
Carica papaya leaves have been used in folk medicine for centuries. In addition to the nutritional value of its fruit, the leaves of C. papaya possess medicinal properties and are widely used in traditional medicines. Th...
Determining the optimal portal blood volume in a shunt before surgery in extrahepatic portal hypertension
The aim of the study: To determine the necessary shunt diameter and assess the optimal portal blood volume in a shunt in children with extrahepatic portal hypertension before the portosystemic shunt surgery. Changes in t...
Effects of Hydrotherapy on postural control and electromyography parameters in men with chronic non-specific low back pain
The aim of this study was to evaluate effects of hydrotherapy on postural control and electromyography parameters in men with chronic non-specific low back pain. Thirty men with chronic non-specific LBP divided into two...
Sero-epidemiology and risk factors of Hepatitis E among pregnant women in Tabriz, Iran
Hepatitis E Virus (HEV) in pregnant women is more severe, often leading to fulminates hepatic failure, death in mother, abortion and death of infants. The aim of this study was to determine the Sero-epidemiology and risk...