L-ARGININE SUPPLEMENTATION IMPROVES INSULIN RESISTANCE BY INCREASING THE INSULIN RECEPTOR EXPRESSION IN TYPE II DIABETIC RATS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 8
Abstract
Background: L-arginine is a multifactorial compound, indirectly involved in multiple regulatory mechanisms substrate for nitric acid synthesis. It has been documented that it has a beneficial effect on insulin resistance in Type 2 Diabetes (T2D) and visceral obesity. Experimental and clinical trials have illustrated the undergoing mechanistic pathways either on molecular or biochemical levels. However, the relationship between L-arginine supplementation and insulin receptor expression has not elucidated. Aim: The study aimed to evaluate the influence of L-arginine supplementation on insulin receptor expression, insulin resistance and weight gain in high fat diet fed rats. Subjects& Methods: 48 female albinos with visceral obesity were randomly assigned to either receive a high fat diet for 12 weeks or L- arginine with a dose of 5% in food for the last 8 weeks. Two age groups were enrolled ?adult and old?, Biochemical analysis was performed including: the concentration of insulin receptor expression in visceral fat, plasma insulin receptor and fasting blood glucose, the insulin resistance was evaluated according to the homeostasis model assessment- insulin resistance (HOMA-IR) protocol. Results: The concentration of insulin receptors was significantly higher in L-arginine treated group and associated with significant decrease in HOMA_IR and insulin concentration. In addition, the influence of L-arginine is conversely proportional with age. Conclusion: our results supports the hypotheses that dietary L-arginine supplementation results in increase insulin receptors, which could lead to negative feedback on insulin resistance.
Authors and Affiliations
Nashwa EL-Khazragy, Dalia A. Saad.
MARINIZATION OF A TWO-STAGE MIXED STRUCTURED PACKING SCRUBBER FOR SOX ABATEMENT AND CO2 CAPTURE.
In this paper, a practical investigation to evaluate the impact of a two-stage mixed structured packing scrubber for SOx abatement and CO2 capture using amine solutions is presented. The practical test consists to connec...
A NEW SPECIES OF DIMERIA (POACEAE: PANICOIDEAE), FROM MIDDLE ANDAMAN, INDIA.
Dimeria fasciculata (Poaceace) collected from Panchvati, Middle Andaman of the Andaman group of Islands in India is described and illustrated as a new species. Some of its morphological characters resemble with other mem...
CAN DIODE LASER SUPPORT REMINERALIZATION POTENTIAL OF CPP-ACPF ON DEMINERALIZED ENAMEL?.
Recent studies recognized that incorporation of fluoride into the Casein Phospho-Peptide - Amorphous Calcium Phosphate (CPP-ACP) structure forming (CPP-ACPF): (GC MI paste Plus), produced greater remineralization than th...
SCHOOL INTERVENTION PROGRAM TO PROMOTE HEALTHY LIFESTYLE AMONG MALE ADOLESCENT STUDENTS IN KING FAISAL RESIDENTIAL CITY, JEDDAH, WESTERN REGION, 2014-15.
Background: Unhealthy behaviors, physical inactivity, consumption of unhealthy diet and sedentary life style are well known to be associated with overweight and obesity among adults as well as adolescents. These behavior...
INCIDANCE AND RISK FACTOR FOR PRETERM LABOUR IN AL-BATOOL TEACHING HOSPITAL.
Background: The incidence of preterm birth (PTB) continues to rise world-wide. Preterm labour is a multifactorial condition associated with a high risk of neonatal morbidity and mortality, especially at lower gestational...