L-ARGININE SUPPLEMENTATION IMPROVES INSULIN RESISTANCE BY INCREASING THE INSULIN RECEPTOR EXPRESSION IN TYPE II DIABETIC RATS.

Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 8

Abstract

Background: L-arginine is a multifactorial compound, indirectly involved in multiple regulatory mechanisms substrate for nitric acid synthesis. It has been documented that it has a beneficial effect on insulin resistance in Type 2 Diabetes (T2D) and visceral obesity. Experimental and clinical trials have illustrated the undergoing mechanistic pathways either on molecular or biochemical levels. However, the relationship between L-arginine supplementation and insulin receptor expression has not elucidated. Aim: The study aimed to evaluate the influence of L-arginine supplementation on insulin receptor expression, insulin resistance and weight gain in high fat diet fed rats. Subjects& Methods: 48 female albinos with visceral obesity were randomly assigned to either receive a high fat diet for 12 weeks or L- arginine with a dose of 5% in food for the last 8 weeks. Two age groups were enrolled ?adult and old?, Biochemical analysis was performed including: the concentration of insulin receptor expression in visceral fat, plasma insulin receptor and fasting blood glucose, the insulin resistance was evaluated according to the homeostasis model assessment- insulin resistance (HOMA-IR) protocol. Results: The concentration of insulin receptors was significantly higher in L-arginine treated group and associated with significant decrease in HOMA_IR and insulin concentration. In addition, the influence of L-arginine is conversely proportional with age. Conclusion: our results supports the hypotheses that dietary L-arginine supplementation results in increase insulin receptors, which could lead to negative feedback on insulin resistance.

Authors and Affiliations

Nashwa EL-Khazragy, Dalia A. Saad.

Keywords

Related Articles

TEXT INDEPENDENT SPEAKER RECOGNITION SYSTEM USING WAVELET FILTERS.

This paper depicts a new speech feature extraction technique for use in automatic speaker recognition (ASR). Wavelets have been shown to be successful front end processors for speaker recognition. Front-end or feature ex...

PRODUCTION OF BIODIESEL FROM MICROALGAE.

Biodiesel has gained much attention in recent years due to its eco-friendly nature, non-toxic characteristics, biodegradability and lower net carbon cycle compared to conventional diesel fuels. In the current study, pote...

DETERMINANTS OF COST OF EQUITY CAPITAL.

This study aims to identify the effect of information asymmetry, right issue, interest rate, inflation rate, return on asset(ROA), earning per share (EPS), price to earning ratio (PER), debt to equity ratio(DER) to cost...

EFFICACY OF IRBESARTAN/HYDROCHLOROTHIAZIDE COMBINATION REGIMEN IN THE MANAGEMENT OF ESSENTIAL HYPERTENSION IN GULF COUNTRIES.

Hypertension, a common risk factor for cardiovascular disease, is highly prevalent among the Gulf population. International guidelines recommend, in some cases, therapy for the treatment of hypertensive patients. Aims:Ou...

SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF BIOETHANOL PRODUCTION AMOUNT

The continuous increase in global energy demand and need necessitates the availability of new energy sources. The expansion of production of bioethanol will reduce our dependence on petroleum and natural gas, and contrib...

Download PDF file
  • EP ID EP633986
  • DOI 10.21474/IJAR01/9551
  • Views 62
  • Downloads 0

How To Cite

Nashwa EL-Khazragy, Dalia A. Saad. (2019). L-ARGININE SUPPLEMENTATION IMPROVES INSULIN RESISTANCE BY INCREASING THE INSULIN RECEPTOR EXPRESSION IN TYPE II DIABETIC RATS.. International Journal of Advanced Research (IJAR), 7(8), 702-708. https://europub.co.uk/articles/-A-633986