L-Asparaginase Related Thrombotic Complications in Acute Lymphoblastic Leukemia Patients – An Experience from a Tertiary Care Centre
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 4
Abstract
Background: L- Asparaginase is commonly used chemotherapeutic agent in the treatment of acute lymphoblastic leukemia patients. The overall incidence of symptomatic venous thrombosis in acute lymphoblastic leukemia (ALL) varies from 1.5-11%. The risk of thrombotic complications in acute lymphoblastic leukemia (ALL) in children ranges from 1 to 37%. Most of the patients develop thrombosis related to L-asparaginase in the induction phase of chemotherapy. Purpose: To highlight the incidence of life threatening thrombotic complications related to L –Asparginase in acute lymphoblastic leukemia patients. Materials and Methods: This study was carried out retrospectively over a period of ten years. The data was taken from regional cancer registry and was compiled. Conclusions: Early identification and management of life threatening thrombotic complications associated with L-asparaginaseis necessary to improve survival outcome in Acute lymphoblastic leukemia patients.
Authors and Affiliations
Nusrat Bashir
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