Lack of Association between Genetic Markers on Chromosome 16q22-Q24 and Type1 Diabetes in Russian Affected Families.
Journal Title: Croatian Medical Journal - Year 2005, Vol 46, Issue 4
Abstract
Aim. To evaluate whether the T1D susceptibility locus on chromosome 16qcontributes to the genetic susceptibility to T1D in Russian patients. Method. Thirteen microsatellitemarkers, spanning a 47-centimorgan genomic region on 16q22-q24 were evaluated for linkage to T1D in 98Russian multiplex families. Multipoint logarithm of odds (LOD) ratio (MLS) and nonparametric LOD (NPL)values were computed for each marker, using GENEHUNTER 2.1 software. Four microsatellites (D16S422, D16S504,D16S3037, and D16S3098) and 6 biallelic markers in 2 positional candidate genes, ICSBP1 and NQO1, wereadditionally tested for association with T1D in 114 simplex families, using transmission disequilibriumtest (TDT). Results. A peak of linkage (MLS=1.35, NPL=0.91) was shown for marker D16S750, but this wasnot significant (P=0.18). The subsequent linkage analysis in the subset of 46 multiplex families carryinga common risk HLA-DR4 haplotype increased peak MLS and NPL values to 1.77 and 1.22, respectively, butshowed no significant linkage (P=0.11) to T1D in the 16q22-q24 genomic region. TDT analysis failed tofind significant association between these markers and disease, even after the conditioning for the predisposingHLA-DR4 haplotype. Conclusion. Our results did not support the evidence for the susceptibility locusto T1D on chromosome 16q22-24 in the Russian family data set. The lack of association could reflect geneticheterogeneity of type 1 diabetes in diverse ethnic groups.
Authors and Affiliations
Dimitry A Chistiakov, Ana Chernisheva, Kirill V Savost'anov, Rustam I Turakulov, Tamara L Kuraeva, Ivan I Dedov, Valery V Nosikov
Keywords
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Lack of Association between Genetic Markers on Chromosome 16q22-Q24 and Type1 Diabetes in Russian Affected Families.
Aim. To evaluate whether the T1D susceptibility locus on chromosome 16qcontributes to the genetic susceptibility to T1D in Russian patients. Method. Thirteen microsatellitemarkers, spanning a 47-centimorgan genomic regio...