LACK OF PRECISION IN HbA1C VALUES ON VARIANT II IN CASES OF HEMOGLOBIN Q INDIA
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 2
Abstract
This study was carried out to check the precision of HbA1c values on Bio-Rad Variant II in cases of a rare hemoglobin variant Q India. The study was carried out over a three month period on samples collected for HbA1c estimation. Seven out of eleven patients showed variable results of HbA1c with a very high and unacceptable intraday mean coefficient of variation (CV) of 9.93%. We conclude, that the results of HbA1c on Variant II can not be reported without adversely affecting HbA1c as a marker of long-term glycemic control in patients who have hemoglobin Q India. The HbA1c value of these patients needs to be assessed by a different instrument/method or the glycemic control be monitored by an alternate test like serum Fructosamine. KEY WORDS HbA1c, precision, variant hemoglobin, diabetes mellitus Address for Correspondence: Dr. P.K. Nigam Dr Lal PathLabs Pvt Ltd, ‘ESKAY HOUSE’, 54 Hanuman Road, New fluctuations in blood glucose levels (1). HbA1c is formed
Authors and Affiliations
P. K. Nigam , S. Sharma,, R. Sareen , V. Paul , A. Lal
Keywords
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