Landscape of Circular Ribonucleic Acids in Urological Cancers
Journal Title: Translational Research in Urology - Year 2021, Vol 3, Issue 2
Abstract
Urological malignancies are among the most important neoplastic diseases imposing a significant burden on health care systems globally. The current therapeutic measures for these cancers have unsatisfactory results, and comprehensive knowledge of pathways involved in carcinogenesis and progression of these cancers is of utmost importance. Circular Ribonucleic Acids (circRNAs) are a class of non-coding RNAs characterized by their single-stranded covalently closed loops, which exert their regulatory effects mainly by sponging the microRNAs (miRNAs) associated with the regulation of gene expression. In the past few years, several circRNAs have been identified to be implicated in the malignancies of the urinary system. A number of these circRNAs are involved in the common carcinogenic pathways, such as MAPK/ERK, TGF-β, and PI3K-Akt pathways. However, further studies are required to ascertain the exact mechanism of numerous circRNAs in urological cancers and determine their diagnostic, prognostic, and therapeutic roles in patients with these cancers.
Authors and Affiliations
Sina Rashedi
Keywords
Related Articles
- EP ID EP704078
- DOI 10.22034/TRU.2021.286351.1067
- Views 152
- Downloads 0
Liquid Biopsy in Prostate Cancer Diagnosis and Prognosis: A Narrative Review
Prostate cancer involves a considerable percentage of men worldwide and as be postulated; prostate cancer epidemiology is not restricted to a specific country. Despite tremendous efforts that have been made regarding pro...
Unusual Complication of Ewing Sarcoma of Vulva: Case Report
Introduction Primary Ewing sarcoma of the vulva is an extremely rare tumor with less than 10 molecular confirmed reported cases. Urinary retention in this case is an unusual manifestation. Case presentation We describ...
The Effect of Pre-Transplant Psychosocial Problems on Kidney Transplantation Outcomes
Introduction: The present study aimed to evaluate the association between the pre-transplant psychosocial profile and kidney transplant candidates' clinical outcomes. Methods: The present study population included all p...
Laparoscopic Management of Large Upper Ureter Steinstrasse After the Failed Endourologic Measures
Introduction: The steinstrasse or stone street is a rare complication after Shock wave lithotripsy (SWL). The true incidence is unknown but is mentioned between 1-4 % in stone sizes less than 2 cm to 13% in large stones....
Cornus Mas and Urinary Tract Infections Treatment
Urinary tract infections (UTI) are somehow complicated to treat and patients frequently will have the problem of infection recurrence after complete cure. Usually, the UTI treatment is done by antibiotics but the problem...