Abstract

Objective: The purpose of the present study was to assess the acetone and ethanol extracts of Andrographis paniculata against the filarial vector Culex quinquefasciatus. Methods: The ethanol and acetone extracts of plant leaves was used at 25, 50, 100, 200 and 300 ppm dilution in bioassays against second instar larvae of Culex quinquefasciatus. Ten larvae were exposed to the leaf extract at different concentration in a final volume of 100 mL formulation taken in 500 mL of glass bowl. For avoiding error triplicates were maintained. Tap water was taken as control. The larval mortality at different concentrations and in control was recorded 24 hour continuous exposure. Results: The toxicity of ethanol extract of Andrographis paniculata on survival of Culex quinquefasciatus reveals that the mortality is dependent on the dose of the plant extract and also on time of exposure. Highest mortality rate of 20% and 73.3% was recorded in 300 ppm at 3 and 24 h respectively. The similar trend was observed in case of the toxicity of acetone extract. Conclusions: The results of the present study suggest that the leaf extracts of Andrographis paniculata may have the potential to be used as an ideal eco-friendly approach for the control of the filarial vector Culex quinquefasciatus.

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